{{Rsnum
|rsid=1800796
|Gene=IL6
|Chromosome=7
|position=22726627
|Orientation=plus
|GMAF=0.2897
|Gene_s=MIR632
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 0.0 | 7.9 | 92.1
| HCB | 57.8 | 37.8 | 4.4
| JPT | 75.0 | 22.7 | 2.3
| YRI | 1.6 | 16.1 | 82.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 57.8 | 37.8 | 4.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|17996468}} [[rs1800796]] IL-6 572G>C polymorphism (and h.211 haplotype) is associated with [[abdominal aortic aneurysm]] (AAA). The risk allele is C.

{{PMID|17508011}} Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.

{{PMID|18257935|OA=1
}} [[rs1800797]], [[rs1800796]] and [[rs1800795]] have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal [[osteoarthritis]] based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

{{PMID|18449426}} [[rs1800796]] [[coronary artery disease]] 190 affected Asian Indian sibling pairs

{{ neighbor
| rsid = 1800795
| distance = 399
}}
{{ neighbor
| rsid = 1800797
| distance = 25
}}

{{PMID Auto
|PMID=19288024
|Title=Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome.
}}

{{PMID Auto
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|Title=Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
}}
{{PMID Auto
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|Title=Tumor markers and rectal cancer: support for an inflammation-related pathway
|OA=1
}}
{{PMID Auto
|PMID=19387461
|Title=Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
|OA=1
}}

{{PMID Auto
|PMID=20939703
|Title=The Interleukin 6 -572 G&amp;gt;C (rs1800796) Polymorphism Is Associated with the Risk of Developing Acute Coronary Syndrome
}}
{{PMID Auto
|PMID=20954977
|Title=Effect of IL-6 C-572G polymorphism on idiopathic membranous nephropathy risk in a han chinese population
}}
{{PMID Auto
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|Title=[Polymorphism of cytokine genes and human longevity]
}}
{{PMID Auto
|PMID=19506792
|Title=The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort
}}

{{PMID Auto
|PMID=21833041
|Title=Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese
}}

{{PMID Auto
|PMID=22107760
|Title=Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
|OA=1
}}

{{PMID Auto
|PMID=22272811
|Title=Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
|OA=1
}}

{{PMID Auto
|PMID=22457277
|Title=A Functional Single-Nucleotide Polymorphism in Interleukin-6 Promoter is associated with Susceptibility to Tuberculosis
|OA=1
}}

{{PMID Auto
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|Title=Interleukin-6 -634G&gt;C Genetic Polymorphism Is Associated with Prognosis following Surgery for Advanced Thoracic Esophageal Squamous Cell Carcinoma
}}

{{PMID Auto
|PMID=22695063
|Title=Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain
|OA=1
}}

{{PMID Auto
|PMID=22701584
|Title=IL-6-174 G/C and -572 C/G Polymorphisms and Risk of Alzheimer’s Disease
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
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|Title=Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=17003362
|Title=IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies.
}}

{{PMID Auto
|PMID=17416766
|Title=IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.
}}

{{PMID Auto
|PMID=17594514
|Title=Active and passive smoking, IL6, ESR1, and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=17694420
|Title=IL6 genotypes and colon and rectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=17785926
|Title=Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations.
}}

{{PMID Auto
|PMID=18216863
|Title=Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
|OA=1
}}

{{PMID Auto
|PMID=18239642
|Title=Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18276608
|Title=Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
}}

{{PMID Auto
|PMID=18321738
|Title=Is the interleukin-6 haplotype a prognostic factor for sciatica?
}}

{{PMID Auto
|PMID=18436879
|Title=Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18496509
|Title=An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=18500540
|Title=Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18992263
|Title=Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
|OA=1
}}

{{PMID Auto
|PMID=19124510
|Title=Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
|OA=1
}}

{{PMID Auto
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|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19230157
|Title=Immunogenetics of seasonal influenza vaccine response.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19267250
|Title=C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
|OA=1
}}

{{PMID Auto
|PMID=19272152
|Title=IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19503017
|Title=Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.
|OA=1
}}

{{PMID Auto
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|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
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|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19729864
|Title=Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19942621
|Title=An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
|OA=1
}}

{{PMID Auto
|PMID=20031567
|Title=An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20031584
|Title=Genetics of atherothrombotic and lacunar stroke.
|OA=1
}}

{{PMID Auto
|PMID=20059469
|Title=Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20144192
|Title=Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.
|OA=1
}}

{{PMID Auto
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|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=20585578
|Title=The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.
|OA=1
}}

{{PMID Auto
|PMID=20667498
|Title=The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.
}}

{{PMID Auto
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|Title=Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis.
}}

{{PMID Auto
|PMID=23088295
|Title=A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
}}

{{PMID Auto
|PMID=23569034
|Title=Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation
}}

{{PMID Auto
|PMID=23881440
|Title=Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population
}}

{{PMID Auto
|PMID=23415255
|Title=Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study
}}

{{PMID Auto
|PMID=24003533
|Title=Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects
}}

{{PMID Auto
|PMID=24072654
|Title=Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24371367
|Title=Rather than Rs1800796 Polymorphism, Expression of Interleukin-6 is Associated with Disease Progression of Chronic HBV Infection in a Chinese Han Population
|OA=1
}}

{{PMID Auto
|PMID=24530755
|Title=Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population
}}

{{PMID Auto
|PMID=22579472
|Title=The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
}}

{{PMID Auto
|PMID=22711691
|Title=Associations between interleukin-6 gene -174 C/G and -572 C/G polymorphisms and the risk of gastric cancer: a meta-analysis.
}}

{{PMID Auto
|PMID=22714907
|Title=IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.
}}

{{PMID Auto
|PMID=23289913
|Title=Association between the interleukin-6 gene -572 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects.
}}

{{PMID Auto
|PMID=24903966
|Title=The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
}}

{{PMID Auto
|PMID=23991193
|Title=Novel single nucleotide polymorphisms in interleukin 6 affect tacrolimus metabolism in liver transplant patients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}