{{Rsnum
|rsid=1800797
|Gene=IL6
|Chromosome=7
|position=22726602
|Orientation=plus
|GMAF=0.1818
|Gene_s=IL6,MIR632
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 31.0 | 43.4 | 25.7
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 17.5 | 82.5
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.9 | 99.1
| GIH | 1.0 | 20.8 | 78.2
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 32.8 | 67.2
| MKK | 0.0 | 9.6 | 90.4
| TSI | 14.7 | 43.1 | 42.2
| HapMapRevision=28
}}{{PMID|18257935|OA=1
}} [[rs1800797]], [[rs1800796]] and [[rs1800795]] have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal [[osteoarthritis]] based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

{{PMID|18449426}} [[rs1800797]] [[coronary artery disease]] 190 affected Asian Indian sibling pairs

{{ neighbor
| rsid = 1800796
| distance = 25
}}

{{PMID Auto
|PMID=19435922
|Title=Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
}}

{{omim
|desc=INTERLEUKIN 6; IL6
|id=147620
|rsnum=1800797
}}
{{PMID Auto
|PMID=19387461
|Title=Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
|OA=1
}}

{{PMID Auto
|PMID=20175976
|Title=A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis
}}

{{PMID Auto
|PMID=20080841
|Title=Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components
}}
{{PMID Auto
|PMID=21129206
|Title=Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor
|OA=1
}}

{{PMID Auto
|PMID=21917900
|Title=Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform
}}

{{PMID Auto
|PMID=22107760
|Title=Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
|OA=1
}}

{{PMID Auto
|PMID=16449530
|Title=Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=16644865
|Title=Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis.
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17416766
|Title=IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.
}}

{{PMID Auto
|PMID=17594514
|Title=Active and passive smoking, IL6, ESR1, and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=17623760
|Title=Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals.
}}

{{PMID Auto
|PMID=17694420
|Title=IL6 genotypes and colon and rectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=17996468
|Title=Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm.
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=18239642
|Title=Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18276608
|Title=Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
}}

{{PMID Auto
|PMID=18321738
|Title=Is the interleukin-6 haplotype a prognostic factor for sciatica?
}}

{{PMID Auto
|PMID=18420533
|Title=The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs.
|OA=1
}}

{{PMID Auto
|PMID=18496509
|Title=An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18727828
|Title=Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.
|OA=1
}}

{{PMID Auto
|PMID=18781131
|Title=Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19267250
|Title=C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
|OA=1
}}

{{PMID Auto
|PMID=19272152
|Title=IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19359268
|Title=Associations of IL6 polymorphisms with lung function decline and COPD.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19585495
|Title=Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.
}}

{{PMID Auto
|PMID=19698145
|Title=Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20144192
|Title=Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.
|OA=1
}}

{{PMID Auto
|PMID=23050050
|Title=Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up
|OA=1
}}

{{PMID Auto
|PMID=22714907
|Title=IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.
}}

{{PMID Auto
|PMID=24059848
|Title=Interleukin-6 polymorphisms and hematologic malignancy: a re-appraisal of evidence from genetic association studies
}}

{{PMID Auto
|PMID=24974143
|Title=Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis
}}

{{PMID Auto
|PMID=25030201
|Title=Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}