{{Rsnum
|rsid=1800860
|Gene=RET
|Chromosome=10
|position=43111239
|Orientation=plus
|ReferenceAllele=A
|GMAF=0.225
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=RET
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.6 | 48.2 | 48.2
| HCB | 3.0 | 25.9 | 71.1
| JPT | 3.6 | 26.1 | 70.3
| YRI | 0.0 | 19.2 | 80.8
| ASW | 1.8 | 10.5 | 87.7
| CHB | 3.0 | 25.9 | 71.1
| CHD | 6.4 | 24.8 | 68.8
| GIH | 7.9 | 42.6 | 49.5
| LWK | 0.0 | 12.8 | 87.2
| MEX | 31.0 | 39.7 | 29.3
| MKK | 1.3 | 22.1 | 76.6
| TSI | 5.9 | 33.3 | 60.8
| HapMapRevision=28
}}
[[rs1800860]] is a SNP in the [[RET]] ret proto-oncogene.

A study of newborns concluded that Caucasian newborns who were clinically normal and carried a [[rs1800860]](A) allele had kidney volumes 10% smaller and cord blood cystatin C levels 9% higher than those with the [[rs1800860]](G;G) genotype. Since individuals with lower nephron numbers have an increased lifetime risk for essential hypertension or renal insufficiency, this may have clinical consequences in adult life (but this remains to be proven).

{{PMID Auto
|PMID=20454948
|Title=Association analysis of the RET proto-oncogene with Hirschsprung disease in the Han Chinese population of southeastern China
}}

{{PMID Auto
|PMID=18820179
|Title=A common RET variant is associated with reduced newborn kidney size and function.
|OA=1
}}

{{PMID Auto
|PMID=20532249
|Title=Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in the Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=21349203
|Title=Genetic variants in RET and risk of Hirschsprung's disease in Southeastern Chinese: a haplotype-based analysis.
|OA=1
}}

{{PMID Auto
|PMID=21821672
|Title=A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function.
}}

{{PMID Auto
|PMID=24897126
|Title=RET Variants and Haplotype Analysis in a Cohort of Czech Patients with Hirschsprung Disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}