{{Rsnum
|rsid=1800871
|Gene=IL10
|Chromosome=1
|position=206773289
|Orientation=minus
|GMAF=0.4086
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL10
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 66.1 | 32.1 | 1.8
| HCB | 10.3 | 30.8 | 59.0
| JPT | 5.0 | 52.5 | 42.5
| YRI | 25.9 | 55.2 | 19.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 10.3 | 30.8 | 59.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|18930197}} [[rs1800871]](C) carriers are associated with a reduced [[endometriosis]] risk by approximately 2x compared with the common [[rs1800871]](T;T) genotype in a study of 196 Chinese patients.

{{PMID|19210299}} [[rs2222202]] (C/T) (p=0.03) and [[rs1800871]] (C/T) (p=0.05) showed significant allelic associations with pediatric onset [[Crohn's disease]].

{{PMID|19208551}} [[rs1800871]](T) carriers were 3x more likely to have their pregnancies terminate early (<10 weeks) than (C) carriers, based on a study of ~500 pregnancies.

In a study of 1,757 cases of [[Alzheimer's disease]] and 6,295 controls, an interaction was replicated between [[IL6]] genotype [[rs2069837]](A;A) and [[IL10]] genotype [[rs1800871]](C;C). The synergy factor (SF) was 1.63 (CI: 1.10-2.41, p = 0.01), controlling for age, gender and [[ApoE4]] genotype. {{PMID|19698145|OA=1
}}

23andMe reports that each G allele at [[rs1800871]] is associated with 0.6x lower odds of [[Behçet's disease]]. {{PMID|20622879}}

{{ neighbor
| rsid = 1800896
| distance = 263
}}
{{PMID Auto
|PMID=19276283
|Title=Interaction between BCL2 and Interleukin-10 Gene Polymorphisms Alter Outcomes of Diffuse Large B-Cell Lymphoma following Rituximab Plus CHOP Chemotherapy
}}

{{PMID Auto
|PMID=19386798
|Title=Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever
|OA=1
}}
{{PMID Auto
|PMID=19700159
|Title=Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study
}}

{{PMID Auto
|PMID=20388104
|Title=Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications
}}
{{PMID Auto
|PMID=20509889
|Title=The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
|OA=1
}}
{{PMID Auto GWAS
|PMID=20622879
|Trait=Behcet's disease
|Title=Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci
|RiskAllele=T
|Pval=1E-14
|OR=1.45
|ORtxt=[1.32-1.60]
}}
{{PMID Auto
|PMID=20927126
|Title=Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
}}
{{PMID Auto
|PMID=21211963
|Title=Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects
}}

{{PMID Auto
|PMID=21609779
|Title=Association of TNF-? and IL-10 polymorphisms with tuberculosis in Tunisian populations
}}

{{PMID Auto
|PMID=21917900
|Title=Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform
}}

{{PMID Auto
|PMID=22436502
|Title=Interleukin-10-819 promoter polymorphism in association with gastric cancer risk
|OA=1
}}

{{PMID Auto
|PMID=22796266
|Title=Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population
}}

{{PMID|15726497|OA=1
}} Gene-environment interaction effects on the development of immune responses in the 1st year of life.

{{PMID|16449530|OA=1
}} Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

{{PMID|16672419|OA=1
}} Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.

{{PMID|16759385|OA=1
}} Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

{{PMID|16820586|OA=1
}} Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

{{PMID|17215862}} The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

{{PMID|17327408|OA=1
}} Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

{{PMID|17420099}} Association of IL10 promoter polymorphism in Italian Alzheimer's disease.

{{PMID|17592300|OA=1
}} Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

{{PMID|17705862|OA=1
}} Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

{{PMID|17929139}} Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.

{{PMID|17980158}} Genetic variation in interleukin-10 gene and risk of oral cancer.

{{PMID|18041006}} Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection.

{{PMID|18479293|OA=1
}} Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

{{PMID|18598732|OA=1
}} Vaccine immunogenetics: bedside to bench to population.

{{PMID|18633131|OA=1
}} Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

{{PMID|18676870|OA=1
}} Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

{{PMID|18687755|OA=1
}} Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

{{PMID|18781131|OA=1
}} Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

{{PMID|18936436|OA=1
}} Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

{{PMID|18978339|OA=1
}} Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.

{{PMID|19066394|OA=1
}} Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

{{PMID|19356949|OA=1
}} Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

{{PMID|19409109|OA=1
}} Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

{{PMID|19412539|OA=1
}} IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.

{{PMID|19505919|OA=1
}} Toll-like receptor signaling pathway variants and prostate cancer mortality.

{{PMID|19604093|OA=1
}} Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

{{PMID|19673019|OA=1
}} IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

{{PMID|19822020|OA=1
}} Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

{{PMID|19852851|OA=1
}} Asthma and genes encoding components of the vitamin D pathway.

{{PMID|19907653|OA=1
}} Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

{{PMID|19934104|OA=1
}} Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

{{PMID|19996656}} Influence of cytokine gene polymorphisms on prostate-specific antigen recurrence in prostate cancer after radical prostatectomy.

{{PMID|20112337|OA=1
}} Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers.

{{PMID|20299965|OA=1
}} Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.

{{PMID|20525402|OA=1
}} Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

{{PMID|21328800}} Lack of association between the IL-10 gene polymorphisms and features of the metabolic syndrome.

{{PMID|21354456}} The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.

{{PMID|21385363|OA=1
}} Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

{{PMID|21455338|OA=1
}} Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.

{{PMID|22095765}} Joint effects of Epstein-Barr virus and polymorphisms in interleukin-10 and interferon-gamma on breast cancer risk.

{{PMID|22239992}} Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.

{{PMID|22307790}} Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.

{{PMID|22644143}} The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.

{{PMID Auto
|PMID=23148667
|Title=The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development
|OA=1
}}

{{PMID Auto
|PMID=23235789
|Title=IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample
}}

{{PMID Auto
|PMID=23574339
|Title=The Interleukin 10 -819C/T Polymorphism and Cancer Risk: A HuGE Review and Meta-Analysis of 73 Studies Including 15,942 Cases and 22,336 Controls
|OA=1
}}

{{PMID Auto
|PMID=23668806
|Title=Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
|OA=1
}}

{{PMID Auto
|PMID=23299779
|Title=Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
|OA=1
}}

{{PMID Auto
|PMID=24003533
|Title=Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects
}}

{{PMID Auto
|PMID=24060592
|Title=The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients
}}

{{PMID Auto
|PMID=24072654
|Title=Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24128120
|Title=The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis
}}

{{PMID Auto
|PMID=24151497
|Title=Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria
|OA=1
}}

{{PMID Auto
|PMID=24269690
|Title=IL10 polymorphisms associated with Behçet's disease in Chinese Han
}}

{{PMID Auto
|PMID=24449078
|Title=Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children
}}

{{PMID Auto
|PMID=24603720
|Title=Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=22749237
|Title=Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.
|OA=1
}}

{{PMID Auto
|PMID=22818022
|Title=Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.
}}

{{PMID Auto
|PMID=23430974
|Title=Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.
}}

{{PMID Auto
|PMID=23640160
|Title=IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.
}}

{{PMID Auto
|PMID=24758873
|Title=Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population
}}

{{PMID Auto
|PMID=24008079
|Title=Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts
}}

{{PMID Auto
|PMID=24903972
|Title=Genetic predisposition to calcific aortic stenosis and mitral annular calcification
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}