{{Rsnum
|rsid=1800872
|Gene=IL10
|Chromosome=1
|position=206773062
|Orientation=minus
|GMAF=0.4091
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=IL10
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 5.3 | 31.9 | 62.8
| HCB | 57.1 | 33.1 | 9.8
| JPT | 39.8 | 51.3 | 8.8
| YRI | 23.1 | 49.0 | 27.9
| ASW | 14.0 | 45.6 | 40.4
| CHB | 57.1 | 33.1 | 9.8
| CHD | 41.3 | 52.3 | 6.4
| GIH | 15.8 | 47.5 | 36.6
| LWK | 11.0 | 54.1 | 34.9
| MEX | 15.8 | 43.9 | 40.4
| MKK | 12.2 | 50.0 | 37.8
| TSI | 7.8 | 37.3 | 54.9
| HapMapRevision=28
}}The [[IL10]] C627A polymorphism in the anti-inﬂammatory Interleukin 10 gene decreases gene transcription. 
[http://clincancerres.aacrjournals.org/cgi/content/abstract/14/12/3777 Effect of Interleukin-10 Gene Polymorphisms on Clinical Outcome of Patients with Aggressive Non-Hodgkin's Lymphoma]. An exploratory study with negative results.

{{PMID|19208551}} [[rs1800872]](A) carriers were 3x more likely to have their pregnancies terminate early (<10 weeks) than (C) carriers, based on a study of ~500 pregnancies.

{{PMID Auto
|PMID=19276283
|Title=Interaction between BCL2 and Interleukin-10 Gene Polymorphisms Alter Outcomes of Diffuse Large B-Cell Lymphoma following Rituximab Plus CHOP Chemotherapy
}}

{{PMID Auto
|PMID=19386798
|Title=Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever
|OA=1
}}
{{PMID Auto
|PMID=19700159
|Title=Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study
}}

{{PMID Auto
|PMID=20031567
|Title=An Evaluation of Candidate Genes of Inflammation and Thrombosis in Relation to the Risk of Venous Thromboembolism: The Women's Genome Health Study
|OA=1
}}

{{PMID Auto
|PMID=20388104
|Title=Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications
}}
{{PMID Auto
|PMID=20509889
|Title=The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
|OA=1
}}
{{PMID Auto
|PMID=20927126
|Title=Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
}}
{{PMID Auto
|PMID=21211963
|Title=Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects
}}
{{PMID Auto
|PMID=21239167
|Title=TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer
}}

{{PMID Auto
|PMID=21609779
|Title=Association of TNF-? and IL-10 polymorphisms with tuberculosis in Tunisian populations
}}

{{PMID Auto
|PMID=21855833
|Title=Replication of Genetic Association Studies in Aortic Stenosis in Adults
}}

{{PMID Auto
|PMID=21917900
|Title=Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform
}}

{{PMID Auto
|PMID=22479352
|Title=The Role of Inflammatory Pathway Genetic Variation on Maternal Metabolic Phenotypes during Pregnancy
|OA=1
}}

{{PMID Auto
|PMID=22594912
|Title=Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
|OA=1
}}

{{PMID Auto
|PMID=22666399
|Title=Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=22715992
|Title=Association of interleukin-10 gene promoter polymorphism in allergic patients
}}

{{PMID|15726497|OA=1
}} Gene-environment interaction effects on the development of immune responses in the 1st year of life.

{{PMID|16449530|OA=1
}} Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

{{PMID|16600026|OA=1
}} Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

{{PMID|16672072|OA=1
}} The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.

{{PMID|16820586|OA=1
}} Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

{{PMID|16846490|OA=1
}} Lemierre's syndrome and genetic polymorphisms: a case report.

{{PMID|16959027|OA=1
}} Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.

{{PMID|17215862}} The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

{{PMID|17327408|OA=1
}} Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

{{PMID|17552041}} Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.

{{PMID|17592300|OA=1
}} Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

{{PMID|17665434|OA=1
}} Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.

{{PMID|17705862|OA=1
}} Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

{{PMID|17929139}} Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.

{{PMID|17980158}} Genetic variation in interleukin-10 gene and risk of oral cancer.

{{PMID|18307517|OA=1
}} Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.

{{PMID|18479293|OA=1
}} Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

{{PMID|18559596}} Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.

{{PMID|18598732|OA=1
}} Vaccine immunogenetics: bedside to bench to population.

{{PMID|18633131|OA=1
}} Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

{{PMID|18676870|OA=1
}} Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

{{PMID|18687755|OA=1
}} Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

{{PMID|18781131|OA=1
}} Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|18936436|OA=1
}} Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

{{PMID|19066394|OA=1
}} Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

{{PMID|19087313|OA=1
}} Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.

{{PMID|19131662|OA=1
}} A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

{{PMID|19264973|OA=1
}} Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

{{PMID|19330901|OA=1
}} Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

{{PMID|19347053|OA=1
}} Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

{{PMID|19409109|OA=1
}} Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

{{PMID|19412539|OA=1
}} IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.

{{PMID|19458621}} Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.

{{PMID|19505919|OA=1
}} Toll-like receptor signaling pathway variants and prostate cancer mortality.

{{PMID|19559392|OA=1
}} A candidate gene association study of 77 polymorphisms in migraine.

{{PMID|19604093|OA=1
}} Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

{{PMID|19673019|OA=1
}} IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

{{PMID|19852851|OA=1
}} Asthma and genes encoding components of the vitamin D pathway.

{{PMID|19907653|OA=1
}} Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

{{PMID|19934104|OA=1
}} Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

{{PMID|20041166|OA=1
}} Common genetic variation and the control of HIV-1 in humans.

{{PMID|20196868|OA=1
}} Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

{{PMID|20299965|OA=1
}} Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.

{{PMID|20463618|OA=1
}} Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

{{PMID|20525402|OA=1
}} Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

{{PMID|20565774|OA=1
}} Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

{{PMID|20725607|OA=1
}} CCL3 genotype and current depression increase risk of HIV-associated dementia.

{{PMID|20737205}} The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{PMID|20865317}} Lack of association between two SNPs (rs1800896 and rs1800872) in IL-10 gene promoter and breast cancer in Caucasians.

{{PMID|21354456}} The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.

{{PMID|21424183}} An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.

{{PMID|22239992}} Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.

{{PMID|22372709}} Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.

{{PMID|22644143}} The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.

{{PMID Auto
|PMID=23079832
|Title=Meta-analysis of epidemiological studies of  association of two polymorphisms in the interleukin-10 gene promoter and colorectal  cancer risk
}}

{{PMID Auto
|PMID=23148667
|Title=The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development
|OA=1
}}

{{PMID Auto
|PMID=23235789
|Title=IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample
}}

{{PMID Auto
|PMID=22859398
|Title=Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence
|OA=1
}}

{{PMID Auto
|PMID=23668806
|Title=Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
|OA=1
}}

{{PMID Auto
|PMID=23086128
|Title=Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer
}}

{{PMID Auto
|PMID=23840460
|Title=Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=23299779
|Title=Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
|OA=1
}}

{{PMID Auto
|PMID=23880623
|Title=Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4-infected Children
}}

{{PMID Auto
|PMID=23886125
|Title=Interleukin 10 rs1800872 T&gt;G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population
}}

{{PMID Auto
|PMID=24003533
|Title=Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects
}}

{{PMID Auto
|PMID=24040186
|Title=Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a chinese general population
|OA=1
}}

{{PMID Auto
|PMID=24060592
|Title=The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients
}}

{{PMID Auto
|PMID=24072654
|Title=Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24128120
|Title=The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis
}}

{{PMID Auto
|PMID=24151497
|Title=Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria
|OA=1
}}

{{PMID Auto
|PMID=24194923
|Title=Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
|OA=1
}}

{{PMID Auto
|PMID=24327156
|Title=[Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease]
}}

{{PMID Auto
|PMID=24449078
|Title=Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children
}}

{{PMID Auto
|PMID=24603720
|Title=Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=22818022
|Title=Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.
}}

{{PMID Auto
|PMID=23133602
|Title=Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.
|OA=1
}}

{{PMID Auto
|PMID=23430974
|Title=Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.
}}

{{PMID Auto
|PMID=23459936
|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=23640160
|Title=IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.
}}

{{PMID Auto
|PMID=23790189
|Title=Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population.
}}

{{PMID Auto
|PMID=24758873
|Title=Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population
}}

{{PMID Auto
|PMID=24008079
|Title=Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts
}}

{{PMID Auto
|PMID=24903972
|Title=Genetic predisposition to calcific aortic stenosis and mitral annular calcification
}}

{{PMID Auto
|PMID=24982395
|Title=Significant Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Taiwan
}}

{{PMID Auto
|PMID=23951054
|Title=The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients
}}

{{PMID Auto
|PMID=25189915
|Title=Effects of Interleukin-10 Polymorphisms and Smoking on the Risk of Gastric Cancer in Taiwan
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}