{{Rsnum
|rsid=1800896
|Gene=IL10
|Chromosome=1
|position=206773552
|Orientation=minus
|GMAF=0.3026
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL10
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 21.2 | 51.3 | 27.4
| HCB | 90.4 | 9.6 | 0.0
| JPT | 91.2 | 8.0 | 0.9
| YRI | 54.1 | 37.0 | 8.9
| ASW | 43.9 | 42.1 | 14.0
| CHB | 90.4 | 9.6 | 0.0
| CHD | 88.1 | 11.9 | 0.0
| GIH | 54.0 | 38.0 | 8.0
| LWK | 38.9 | 50.0 | 11.1
| MEX | 46.6 | 44.8 | 8.6
| MKK | 30.8 | 56.4 | 12.8
| TSI | 37.3 | 36.3 | 26.5
| HapMapRevision=28
}}
This SNP is upstream of the [[IL10]] gene, and is also known as the -1082G>A IL10 SNP.

{{PMID|18440625}} Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations.

Dust mite exposure significantly modified the relation between 3 SNPs in IL10 ([[rs1800896]], [[rs3024492]], and [[rs3024496]]). Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence ( approximately 3-fold to 39-fold increase).

A study of 258 [[prostate cancer]] cases concluded that the [[rs1800896]](A) allele, known to result in lower levels of this anti-inflammatory cytokine, was positively associated with risk (AG vs. GG, odds ratio of 1.69, CI: 1.10-2.60; AA vs. GG, OR of 1.81, CI: 1.11-2.96).{{PMID|19267370|OA=1
}}

{{ neighbor
| rsid = 1800871
| distance = 263
}}

{{PMID Auto
|PMID=19386798
|Title=Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever
|OA=1
}}
{{PMID Auto
|PMID=19700159
|Title=Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study
}}
{{PMID Auto
|PMID=19760027
|Title=Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
}}

{{PMID Auto
|PMID=20388104
|Title=Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications
}}
{{PMID Auto
|PMID=20509889
|Title=The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
|OA=1
}}
{{PMID Auto
|PMID=20927126
|Title=Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
}}
{{PMID Auto
|PMID=21211963
|Title=Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects
}}
{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis
|OA=1
}}

{{PMID Auto
|PMID=21447951
|Title=Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis
}}

{{PMID Auto
|PMID=22615793
|Title=Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population
|OA=1
}}

{{PMID Auto
|PMID=22144535
|Title=Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study
|OA=1
}}

{{PMID Auto
|PMID=22715992
|Title=Association of interleukin-10 gene promoter polymorphism in allergic patients
}}

{{PMID Auto
|PMID=22825546
|Title=The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16449530
|Title=Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
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|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=16672072
|Title=The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.
|OA=1
}}

{{PMID Auto
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|Title=Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
|OA=1
}}

{{PMID Auto
|PMID=16759385
|Title=Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=17215862
|Title=The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.
}}

{{PMID Auto
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|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17355643
|Title=Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
|OA=1
}}

{{PMID Auto
|PMID=17420099
|Title=Association of IL10 promoter polymorphism in Italian Alzheimer's disease.
}}

{{PMID Auto
|PMID=17552041
|Title=Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.
}}

{{PMID Auto
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|Title=Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.
|OA=1
}}

{{PMID Auto
|PMID=17665434
|Title=Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.
|OA=1
}}

{{PMID Auto
|PMID=17690160
|Title=Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=17929139
|Title=Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.
}}

{{PMID Auto
|PMID=18307517
|Title=Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.
|OA=1
}}

{{PMID Auto
|PMID=18479293
|Title=Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.
|OA=1
}}

{{PMID Auto
|PMID=18559596
|Title=Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.
}}

{{PMID Auto
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|Title=Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
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|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
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|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

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|OA=1
}}

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|OA=1
}}

{{PMID Auto
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|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
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|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
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|OA=1
}}

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{{PMID Auto
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|Title=Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.
|OA=1
}}

{{PMID Auto
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|Title=IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.
|OA=1
}}

{{PMID Auto
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|Title=Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
|OA=1
}}

{{PMID Auto
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|Title=IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
|OA=1
}}

{{PMID Auto
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|Title=Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
|OA=1
}}

{{PMID Auto
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|Title=Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.
}}

{{PMID Auto
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|Title=Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.
|OA=1
}}

{{PMID Auto
|PMID=19852851
|Title=Asthma and genes encoding components of the vitamin D pathway.
|OA=1
}}

{{PMID Auto
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|Title=Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
|OA=1
}}

{{PMID Auto
|PMID=20031567
|Title=An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20047977
|Title=Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
|OA=1
}}

{{PMID Auto
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|Title=Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
|OA=1
}}

{{PMID Auto
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|Title=Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.
|OA=1
}}

{{PMID Auto
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|Title=Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.
}}

{{PMID Auto
|PMID=20406895
|Title=Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=20444268
|Title=Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
|OA=1
}}

{{PMID Auto
|PMID=20459687
|Title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
|OA=1
}}

{{PMID Auto
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|Title=Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
|OA=1
}}

{{PMID Auto
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|Title=The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk.
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=20865317
|Title=Lack of association between two SNPs (rs1800896 and rs1800872) in IL-10 gene promoter and breast cancer in Caucasians.
}}

{{PMID Auto
|PMID=21030268
|Title=Interleukin-10-1082 promoter polymorphism and ischemic stroke risk in a South Indian population.
}}

{{PMID Auto
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|Title=The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.
}}

{{PMID Auto
|PMID=21448414
|Title=Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
|OA=1
}}

{{PMID Auto
|PMID=21455338
|Title=Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.
|OA=1
}}

{{PMID Auto
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|Title=The -1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: a meta-analysis.
}}

{{PMID Auto
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|Title=Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
}}

{{PMID Auto
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|Title=Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.
}}

{{PMID Auto
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|Title=Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.
}}

{{PMID Auto
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|Title=Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.
}}

{{PMID Auto
|PMID=22644143
|Title=The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.
}}

{{PMID Auto
|PMID=23079832
|Title=Meta-analysis of epidemiological studies of  association of two polymorphisms in the interleukin-10 gene promoter and colorectal  cancer risk
}}

{{PMID Auto
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|Title=The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development
|OA=1
}}

{{PMID Auto
|PMID=23235789
|Title=IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample
}}

{{PMID Auto
|PMID=22859398
|Title=Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence
|OA=1
}}

{{PMID Auto
|PMID=23415626
|Title=Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: A meta-analysis
}}

{{PMID Auto
|PMID=23668806
|Title=Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
|OA=1
}}

{{PMID Auto
|PMID=23299779
|Title=Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
|OA=1
}}

{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=IL28B and IL10R -1087 polymorphisms are protective for chronic genotype 1 HCV infection and predictors of response to interferon-based therapy in an East-Central European cohort
|OA=1
}}

{{PMID Auto
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|Title=Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

{{PMID Auto
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}}

{{PMID Auto
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}}

{{PMID Auto
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|Title=The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project.
}}

{{PMID Auto
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|Title=Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease.
}}

{{PMID Auto
|PMID=23857017
|Title=Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.
}}

{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}