{{Rsnum
|rsid=1800947
|Gene=CRP
|Chromosome=1
|position=159713648
|Orientation=minus
|ReferenceAllele=G
|GMAF=0.04132
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=C allele linked to lower CRP levels
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CRP
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 0.0 | 13.8 | 86.2
| HCB | 0.0 | 13.3 | 86.7
| JPT | 0.0 | 6.8 | 93.2
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 13.3 | 86.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}Although somewhat lacking in statistical power, several reports have linked [[rs1800947]], a synonymous mutation known as CRP2 in the C-reactive protein [[CRP]] to the autoimmune disorder [[SLE]], systemic lupus erythematosus. The risk allele in dbSNP orientation is (C). [PMID 14645206, PMID 15897982, PMID 18216863]

[http://7thspace.com/headlines/308756/c_reactive_protein_gene_variants_are_associated_with_postoperative_c_reactive_protein_levels_after_coronary_artery_bypass_surgery.html news] C linked to lower CRP levels

{{omim
|desc=C-REACTIVE PROTEIN, PENTRAXIN-RELATED; CRP
|id=123260
|quiet=1
|rsnum=1800947
|variant=
}}

{{PMID Auto
|PMID=19040303
|Title=C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain
}}

{{PMID Auto
|PMID=19426506
|Title=C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery
|OA=1
}}
{{PMID Auto
|PMID=19436291
|Title=C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk
|OA=1
}}

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
|id=152700
|rsnum=1800947
}}
{{PMID Auto
|PMID=19101671
|Title=Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity
}}
{{PMID Auto
|PMID=19692124
|Title=Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration
}}

{{PMID Auto
|PMID=19821022
|Title=Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
}}
{{PMID Auto
|PMID=20552244
|Title=Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia
}}
{{PMID Auto
|PMID=20733302
|Title=Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke
}}
{{PMID Auto
|PMID=20333461
|Title=Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population
}}
{{PMID Auto
|PMID=20949557
|Title=Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival
|OA=1
}}

{{PMID Auto
|PMID=21293934
|Title=Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer
}}

{{omim
|id=613145
|rsnum=1800947
}}

{{PMID Auto
|PMID=21413847
|Title=Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey
}}

{{PMID Auto
|PMID=21080913
|Title=The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=16550411
|Title=Allelic spectrum of the natural variation in CRP.
|OA=1
}}

{{PMID Auto
|PMID=16723442
|Title=A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=16733231
|Title=Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=16832152
|Title=Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.
}}

{{PMID Auto
|PMID=17355643
|Title=Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
|OA=1
}}

{{PMID Auto
|PMID=17888441
|Title=Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=17900590
|Title=C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.
}}

{{PMID Auto
|PMID=17956875
|Title=DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.
}}

{{PMID Auto
|PMID=18000615
|Title=Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.
}}

{{PMID Auto
|PMID=18167554
|Title=C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.
|OA=1
}}

{{PMID Auto
|PMID=18394581
|Title=Bayesian meta-analysis of genetic association studies with different sets of markers.
|OA=1
}}

{{PMID Auto
|PMID=18426996
|Title=Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.
|OA=1
}}

{{PMID Auto
|PMID=18439548
|Title=Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18499652
|Title=C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study.
}}

{{PMID Auto
|PMID=18500540
|Title=Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
|OA=1
}}

{{PMID Auto
|PMID=18704199
|Title=Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18793001
|Title=Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.
|OA=1
}}

{{PMID Auto
|PMID=18974842
|Title=Gender differences in genetic risk profiles for cardiovascular disease.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19075099
|Title=Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.
}}

{{PMID Auto
|PMID=19076828
|Title=Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.
|OA=1
}}

{{PMID Auto
|PMID=19095725
|Title=Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.
|OA=1
}}

{{PMID Auto
|PMID=19267250
|Title=C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
|OA=1
}}

{{PMID Auto
|PMID=19272152
|Title=IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19410251
|Title=Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.
}}

{{PMID Auto
|PMID=19762396
|Title=Factors associated with arterial vascular events in PROFILE: a Multiethnic Lupus Cohort.
|OA=1
}}

{{PMID Auto
|PMID=19796676
|Title=Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.
|OA=1
}}

{{PMID Auto
|PMID=19906786
|Title=Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.
|OA=1
}}

{{PMID Auto
|PMID=20616999
|Title=Usefulness of Mendelian randomization in observational epidemiology.
|OA=1
}}

{{PMID Auto
|PMID=21034294
|Title=C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.
}}

{{PMID Auto
|PMID=21325005
|Title=Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.
|OA=1
}}

{{PMID Auto
|PMID=21647738
|Title=Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|OA=1
}}

{{PMID Auto
|PMID=21773944
|Title=Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.
}}

{{PMID Auto
|PMID=21790705
|Title=The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics.
}}

{{PMID Auto
|PMID=21979869
|Title=C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.
|OA=1
}}

{{PMID Auto
|PMID=23254959
|Title=Serum C-reactive protein and risk of lung cancer: a case-control study
}}

{{PMID Auto
|PMID=23397258
|Title=Association study of CRP gene in systemic sclerosis in European Caucasian population.
}}

{{PMID Auto
|PMID=24844401
|Title=Genetic variation across C-reactive protein and risk of prostate cancer
}}

{{PMID Auto
|PMID=24862635
|Title=Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)
}}

{{PMID Auto
|PMID=24894103
|Title=Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}