{{Rsnum
|rsid=1801020
|Gene=F12
|Chromosome=5
|position=177409531
|Orientation=minus
|GMAF=0.4201
|Gene_s=F12
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 70.8 | 21.2 | 8.0
| HCB | 8.0 | 46.0 | 46.0
| JPT | 7.1 | 46.9 | 46.0
| YRI | 21.8 | 44.9 | 33.3
| ASW | 42.1 | 40.4 | 17.5
| CHB | 8.0 | 46.0 | 46.0
| CHD | 5.5 | 42.2 | 52.3
| GIH | 22.8 | 52.5 | 24.8
| LWK | 31.8 | 56.4 | 11.8
| MEX | 36.2 | 46.6 | 17.2
| MKK | 22.4 | 48.1 | 29.5
| TSI | 65.7 | 34.3 | 0.0
| HapMapRevision=28
}}Affects [[heart disease]] risk for both men and women, based on a study of two Finnish population cohorts (HR = 1.31 (1.08-1.60) for CVD, uncorrected p = 0.006 multiplicative model).{{PMID|19874842|OA=1
}}

{{PMID|21071604}} A meta-analysis of publications through July 2009, totaling 4,386 cases (vs 40,089 controls) concluded that apart from a very weak association with [[myocardial infarction]] for the [[rs1801020]] (T;T) + (C;T) compared with (C;C) genotype, (odds ratio 1.13, CI: 1.00 - 1.27), the evidence for an association between F12 -4C>T and venous thromboembolism and myocardial infarction was weak.

{{PMID Auto
|PMID=19786295
|Title=Combined cis-regulator elements as important mechanism affecting FXII plasma levels
|OA=1
}}

{{omim
|id=610619
|desc=COAGULATION FACTOR XII; F12
|rsnum=1801020
}}
{{PMID Auto
|PMID=21071604
|Title=The Factor XII -4C&gt;T Variant and Risk of Common Thrombotic Disorders: A HuGE Review and Meta-Analysis of Evidence From Observational Studies
}}

{{omim
|id=188050
|rsnum=1801020
}}

{{omim
|id=610619
|rsnum=1801020
|variant=0004
}}

{{PMID Auto
|PMID=18974842
|Title=Gender differences in genetic risk profiles for cardiovascular disease.
|OA=1
}}

{{PMID Auto
|PMID=19372376
|Title=Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
|OA=1
}}

{{PMID Auto
|PMID=19933701
|Title=Sequence variation and genetic evolution at the human F12 locus: mapping quantitative trait nucleotides that influence FXII plasma levels.
|OA=1
}}

{{PMID Auto
|PMID=20346176
|Title=The Mediterranean Sea as a barrier to gene flow: evidence from variation in and around the F7 and F12 genomic regions.
|OA=1
}}

{{PMID Auto
|PMID=22388798
|Title=Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
|OA=1
}}

{{PMID Auto
|PMID=23150947
|Title=Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}