{{Rsnum
|rsid=1801155
|Gene=APC
|Chromosome=5
|position=112839514
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=A
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=APC
}}also known as [[rs28933380]] related to [[colorectal cancer]], FAMILIAL, [[Ashkenazi]]
* [http://www.hopkins-gi.org/GDL_Disease.aspx?CurrentUDV=31&GDL_Disease_ID=BDC08134-FE49-4DED-949B-DA70A91126C5&GDL_DC_ID=D03119D7-57A3-4890-A717-CF1E7426C8BA APC l1307K: Introduction - Johns Hopkins Hereditary Colorectal Cancer Website]

{{ neighbor
| rsid = 28933379
| distance = 561
}}
{{ neighbor
| rsid = 28933380
| distance = 1
}}

{{omim
|id=611731
|rsnum=1801155
|variant=0029
}}

{{ClinVar
|rsid=1801155
|Reversed=0
|FwdREF=T
|FwdALT=A
|REF=T
|ALT=A
|RSPOS=112175211
|CHROM=5
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050168000000040002110100
|GENEINFO=APC:324
|GENE_NAME=APC
|GENE_ID=324
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000005.9:g.112175211T>A
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1345; 611731.0029
|CLNSIG=255
|CLNCUI=CN068448; CN074282
|CLNDBN=Adenomatous polyposis coli, susceptibility to; Breast cancer, susceptibility to; Adenomatous polyposis coli; not provided
|Disease=Adenomatous polyposis coli; Breast cancer; Adenomatous polyposis coli; not provided
|CLNACC=RCV000000864.2; RCV000000865.2; RCV000020088.1; RCV000034388.1
|Tags=PM;PMC;SLO;VLD;OTHERKG;LSD;OM
|CLNDSDB=MedGen; GeneReviews:MedGen:OMIM:Orphanet:Orphanet:SNOMED_CT
|CLNDSDBID=CN068448; NBK1345:CN074282:175100:220460:733:70921007
}}

{{PMID Auto
|PMID=14624392
|Title=Genetic Anthropology of the Colorectal Cancer–Susceptibility Allele APC I1307K: Evidence of Genetic Drift within the Ashkenazim
|OA=1
}}

{{PMID Auto
|PMID=9288102
|Title=Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
}}

{{PMID Auto
|PMID=9724771
|Title=The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
|OA=1
}}

{{PMID Auto
|PMID=15208782
|Title=A population-genetic test of founder effects and implications for Ashkenazi Jewish diseases.
|OA=1
}}

{{PMID Auto
|PMID=20470408
|Title=How old is this mutation? - a study of three Ashkenazi Jewish founder mutations.
|OA=1
}}

{{PMID Auto
|PMID=9751605
|Title=Somatic instability of the APC I1307K allele in colorectal neoplasia.
}}

{{PMID Auto
|PMID=9869620
|Title=Cancer, crash sites, and the new genetics of neoplasia.
}}

{{PMID Auto
|PMID=9973276
|Title=Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
|OA=1
}}

{{PMID Auto
|PMID=11001924
|Title=Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
}}

{{PMID Auto
|PMID=23896379
|Title=The APC p.I1307K polymorphism is a significant risk factor for CRC in average risk Ashkenazi Jews.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}