{{Rsnum
|rsid=1801157
|Gene=CXCL12
|Chromosome=10
|position=44868257
|Orientation=minus
|GMAF=0.208
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
[[rs1801157]], also known as G801A, is a SNP in the chemokine (C-X-C motif) ligand 12 [[CXCL12]] gene.

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 34.5 | 61.9
| HCB | 9.5 | 31.4 | 59.1
| JPT | 8.8 | 39.8 | 51.3
| YRI | 0.0 | 4.1 | 95.9
| ASW | 0.0 | 16.1 | 83.9
| CHB | 9.5 | 31.4 | 59.1
| CHD | 9.2 | 39.4 | 51.4
| GIH | 9.9 | 45.5 | 44.6
| LWK | 0.0 | 12.8 | 87.2
| MEX | 1.7 | 29.3 | 69.0
| MKK | 1.3 | 12.8 | 85.9
| TSI | 8.8 | 35.3 | 55.9
| HapMapRevision=28
}}rs1801157(A)  was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). {{PMID|16177829}} [[HIV]]-1/[[AIDS]]

A 2011 meta-analysis (comprising 5 studies totaling 1,058 cases) found that the [[rs1801157]](A) allele was associated with higher risk for [[breast cancer]], with an odds ratio of 1.44 (CI: 1.2 - 1.7; under a dominant model).{{PMID|21643956}}

{{PMID Auto
|PMID=19601773
|Title=Molecular phenotype of CXCL12beta 3' UTR G801A polymorphism (rs1801157) associated to HIV-1 disease progression
}}
{{PMID Auto
|PMID=19788587
|Title=Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study
|OA=1
}}
{{PMID Auto
|PMID=19821058
|Title=Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population
}}

{{PMID Auto
|PMID=19927352
|Title=CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non-hodgkin's lymphoma
}}

{{PMID Auto
|PMID=20406099
|Title=CXCL12-3' G801A Polymorphism Is Not a Risk Factor for Breast Cancer
}}

{{PMID Auto
|PMID=22166550
|Title=Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population
}}

{{PMID Auto
|PMID=22699677
|Title=CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17509149
|Title=Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
|OA=1
}}

{{PMID Auto
|PMID=17848170
|Title=The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=17982648
|Title=Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer.
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19115008
|Title=SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19196101
|Title=Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19327121
|Title=Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma.
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=19956109
|Title=The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
|OA=1
}}

{{PMID Auto
|PMID=20041166
|Title=Common genetic variation and the control of HIV-1 in humans.
|OA=1
}}

{{PMID Auto
|PMID=20725607
|Title=CCL3 genotype and current depression increase risk of HIV-associated dementia.
|OA=1
}}

{{PMID Auto
|PMID=21296802
|Title=Haplotype analysis of chemokine CXCL12 polymorphisms and susceptibility to premature ovarian failure in Chinese women.
}}

{{PMID Auto
|PMID=21304904
|Title=Genetic predisposition of donors affects the allograft outcome in kidney transplantation; polymorphisms of stromal-derived factor-1 and CXC receptor 4.
|OA=1
}}

{{PMID Auto
|PMID=21584490
|Title=SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.
}}

{{PMID Auto
|PMID=21592819
|Title=CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients.
}}

{{PMID Auto
|PMID=22962615
|Title=The Role of Genetic Variants of Stromal Cell-Derived Factor 1 in Pediatric HIV-1 Infection and Disease Progression
|OA=1
}}

{{PMID Auto
|PMID=23078136
|Title=Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia
}}

{{PMID Auto
|PMID=23653000
|Title=CXCL12 and TP53 genetic polymorphisms as markers of susceptibility in a Brazilian children population with acute lymphoblastic leukemia (ALL)
}}

{{PMID Auto
|PMID=23711392
|Title=The CXCL12-3'A allele plays a favourable role in patients with multiple myeloma
}}

{{PMID Auto
|PMID=22939870
|Title=The CXCL12 G801A polymorphism and cancer risk: evidence from 17 case-control studies.
}}

{{PMID Auto
|PMID=24950177
|Title=A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients
}}

{{PMID Auto
|PMID=25029540
|Title=Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}