{{Rsnum
|rsid=1801198
|Gene=TCN2
|Chromosome=22
|position=30615623
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.4128
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=TCN2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 35.4 | 43.1 | 21.5
| HCB | 18.2 | 56.8 | 25.0
| JPT | 15.9 | 61.4 | 22.7
| YRI | 63.5 | 36.5 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 18.2 | 56.8 | 25.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{omim
| id = 275350
| variant = 0002
| desc    = TCN2 POLYMORPHISM
| rsnum   = 1801198
}}

{{Venter SNP
|rsid=1801198
|allele=C
|frequency=0.55
|uid=1103691028608
|type=homozygous_SNP
|hugo=TCN2
|ensembl gene=ENSG00000185339
|ensembl transcript=ENST00000215838
|sift=TOLERATED
|disease=Defects in TCN2 are the cause of transcobalamin II deficiency (MIM:275350). This results in various forms of anemia.
}}

{{omim
|id=613441
|rsnum=1801198
|variant=0002
}}

{{PMID Auto
|PMID=21429654
|Title=Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility
}}

{{PMID Auto
|PMID=22794911
|Title=A candidate gene study of one-carbon metabolism pathway genes and colorectal cancer risk
}}

{{ClinVar
|rsid=1801198
|Reversed=0
|FwdREF=G
|FwdALT=C
|REF=G
|ALT=C
|RSPOS=31011610
|CHROM=22
|GMAF=0.413
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05036800000017051f110100
|GENEINFO=TCN2:6948
|GENE_NAME=TCN2
|GENE_ID=6948
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.31011610G>C
|CLNORIGIN=0
|CLNSIG=2
|Tags=PM;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.4128; 0.5872
|CLNACC=RCV000000117.1
|CLNDBN=TCN2 POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=613441.0002
|COMMON=1
|Disease=TCN2 POLYMORPHISM
}}

{{PMID|17035141|OA=1
}} Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.

{{PMID|17220211|OA=1
}} Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).

{{PMID|18203168|OA=1
}} Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts.

{{PMID|18661527|OA=1
}} Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.

{{PMID|19936946|OA=1
}} Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.

{{PMID|20111745|OA=1
}} Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.

{{PMID|21688148|OA=1
}} Polymorphic variants of genes involved in homocysteine metabolism in celiac disease.

{{PMID|22183302}} Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population.

{{GET Evidence
|gene=TCN2
|aa_change=Arg232Pro
|aa_change_short=R232P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1801198
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=5
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23089108
|Title=Idiopathic pulmonary fibrosis and polymorphisms of the folate pathway genes
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}