{{Rsnum
|rsid=1801212
|Gene=WFS1
|Chromosome=4
|position=6300792
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1364
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=WFS1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 61.9 | 34.5 | 3.5
| HCB | 97.8 | 2.2 | 0.0
| JPT | 97.7 | 2.3 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 97.8 | 2.2 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 64.4 | 34.7 | 1.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 70.7 | 25.9 | 3.4
| MKK | 89.7 | 10.3 | 0.0
| TSI | 51.0 | 40.2 | 8.8
| HapMapRevision=28
}}

{{Venter SNP
|rsid=1801212
|allele=A
|frequency=0.808
|uid=1103654325525
|type=homozygous_SNP
|hugo=WFS1
|ensembl gene=ENSG00000109501
|ensembl transcript=ENST00000382615
|sift=TOLERATED
|disease=Defects in WFS1 are the cause of Wolfram syndrome (WFS) (MIM:222300); also known as diabetes insipidus and mellitus with optic atrophy and deafness syndrome (DIDMOAD). It is a rare autosomal recessive disorder characterized by juvenile diabetes mellitus, diabetes insipidus, optic atrophy, deafness and various neurological symptoms.
}}

{{ neighbor
| rsid = 28937892
| distance = 514
}}

{{GET Evidence
|gene=WFS1
|aa_change=Val333Ile
|aa_change_short=V333I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1801212
|overall_frequency_n=8607
|overall_frequency_d=10758
|overall_frequency=0.800056
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=93
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-4
|autoscore=3
|n_web_uneval=2
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}