{{Rsnum
|rsid=1801725
|Gene=CASR
|Chromosome=3
|position=122284910
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.07622
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=CASR
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 75.2 | 23.0 | 1.8
| HCB | 95.6 | 4.4 | 0.0
| JPT | 96.5 | 3.5 | 0.0
| YRI | 97.3 | 2.7 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 95.6 | 4.4 | 0.0
| CHD | 95.4 | 4.6 | 0.0
| GIH | 60.4 | 30.7 | 8.9
| LWK | 97.3 | 2.7 | 0.0
| MEX | 86.2 | 13.8 | 0.0
| MKK | 94.9 | 5.1 | 0.0
| TSI | 63.7 | 32.4 | 3.9
| HapMapRevision=28
}}

{{omim
|desc=CALCIUM, SERUM LEVELS OF
|id=601199
|rsnum=1801725
|variant=0040
}}

{{ neighbor
| rsid = 1042636
| distance = 12
}}

{{PMID Auto
|PMID=19706842
|Title=Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations
}}

{{PMID Auto GWAS
|PMID=20661308
|Trait=None
|Title=Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR)gene
|RiskAllele=T
|Pval=6E-37
|OR=0
|ORtxt=[0.0031-0.0042] increase in log(CASR, mmol/L)
|OA=1
}}

{{ClinVar
|rsid=1801725
|Reversed=0
|FwdREF=G
|FwdALT=T
|REF=G
|ALT=T
|RSPOS=122003757
|CHROM=3
|GMAF=0.076
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05016800000015051f130101
|GENEINFO=CASR:846
|GENE_NAME=CASR
|GENE_ID=846
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.122003757G>T
|CLNORIGIN=1
|CLNSIG=5
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.9238; 0.07622
|CLNACC=RCV000008854.1
|CLNDBN=Serum calcium level
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=601199.0040
|COMMON=1
|Disease=Serum calcium level
}}

{{PMID Auto
|PMID=17309124
|Title=Interaction between birthweight and polymorphism in the calcium-sensing receptor gene in determination of adult bone mass: the Hertfordshire cohort study.
|OA=1
}}

{{PMID Auto
|PMID=18843020
|Title=Genetic variation in calcium-sensing receptor and risk for colon cancer.
|OA=1
}}

{{PMID Auto
|PMID=22278364
|Title=Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European ppulations.
|OA=1
}}

{{PMID Auto
|PMID=23072920
|Title=Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme
|OA=1
}}

{{GET Evidence
|gene=CASR
|aa_change=Ala996Ser
|aa_change_short=A996S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1801725
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23533647
|Title=Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma
|OA=1
}}

{{PMID Auto
|PMID=23125333
|Title=Common genetic variation of the calcium-sensing receptor and lethal prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=23546818
|Title=Vitamin D and calcium-sensing receptor polymorphisms differentially associate with resting energy expenditure in peripubertal children.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}