{{Rsnum
|rsid=180223
|Gene=TG
|Chromosome=8
|position=132888007
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.36
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TG
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 20.4 | 49.6 | 30.1
| HCB | 60.7 | 31.1 | 8.1
| JPT | 53.2 | 43.2 | 3.6
| YRI | 63.7 | 30.1 | 6.2
| ASW | 59.6 | 31.6 | 8.8
| CHB | 60.7 | 31.1 | 8.1
| CHD | 58.7 | 33.9 | 7.3
| GIH | 54.0 | 38.0 | 8.0
| LWK | 51.4 | 40.2 | 8.4
| MEX | 24.6 | 61.4 | 14.0
| MKK | 60.3 | 32.1 | 7.7
| TSI | 32.4 | 50.0 | 17.6
| HapMapRevision=28
}}{{Venter SNP
|rsid=180223
|allele=G
|frequency=0.466
|uid=1103652448042
|type=heterozygous_SNP
|hugo=TG
|ensembl gene=ENSG00000042832
|ensembl transcript=ENST00000220616
|sift=TOLERATED
|disease=Defects in TG are a cause of some forms of goiter (MIM:188450). Goiter is an enlargement of the thyroid gland. This is sometimes linked to hypothyroidism.
}}

{{omim
|id=188450
|rsnum=180223
|variant=0009
}}

{{ClinVar
|rsid=180223
|Reversed=0
|FwdREF=T
|FwdALT=G
|REF=T
|ALT=G
|RSPOS=133900252
|CHROM=8
|GMAF=0.3599
|dbSNPBuildID=79
|SSR=0
|SAO=1
|VP=0x05016000000017051f110100
|GENEINFO=TG:7038
|GENE_NAME=TG
|GENE_ID=7038
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000008.10:g.133900252T>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=188450.0009
|CLNSIG=255
|CLNCUI=C1842444
|CLNDBN=Autoimmune thyroid disease 3
|Disease=Autoimmune thyroid disease 3
|CLNACC=RCV000013534.1
|Tags=PM;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.36; 0.64
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1842444:608175
|COMMON=1
}}

{{GET Evidence
|gene=TG
|aa_change=Ser734Ala
|aa_change_short=S734A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs180223
|overall_frequency_n=6365
|overall_frequency_d=10758
|overall_frequency=0.591653
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=68
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|in_omim=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=3
|webscore=N
|n_web_uneval=6
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}