{{Rsnum
|rsid=1805006
|Gene=MC1R
|Chromosome=16
|position=89919510
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.004132
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=MC1R
}}[[rs1805006]], known as Asp84Glu or D84E, is one of several SNPs in the [[MC1R]] gene associated with higher risk of melanoma. {{PMID|8894704}}

The risk allele is [[rs1805006]](A), compared with the wild-type [[rs1805006]](C) allele.  

Allelic odds ratio for pale skin(P-value)=5.19(<1.0e-5)MC1R*D84E rs1805006 
http://genepi.qimr.edu.au/contents/p/staff/Duffyetal_JID_520-528Jan10.pdf

See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=155555&a=155555_AllelicVariant0003 OMIM 155555.0003]
{{ neighbor
| rsid = 1805005
| distance = 74
}}
{{ neighbor
| rsid = 2228479
| distance = 22
}}

{{omim
|id=155555
|rsnum=1805006
|variant=0003
}}

{{ClinVar
|rsid=1805006
|Reversed=0
|FwdREF=C
|FwdALT=A
|REF=C
|ALT=A
|RSPOS=89985918
|CHROM=16
|GMAF=0.0041
|dbSNPBuildID=89
|SSR=0
|SAO=0
|VP=0x050168000000040516110100
|GENEINFO=MC1R:4157
|GENE_NAME=MC1R
|GENE_ID=4157
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.89985918C>A
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=155555.0003
|CLNSIG=255
|CLNCUI=C2751295
|CLNDBN=Cutaneous malignant melanoma 5
|Disease=Cutaneous malignant melanoma 5
|CLNACC=RCV000015380.1
|Tags=PM;PMC;SLO;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9959; 0.004132
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C2751295:613099:618
|COMMON=1
}}

{{PMID Auto
|PMID=17999355
|Title=A genomewide association study of skin pigmentation in a South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=20670983
|Title=The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}