{{Rsnum
|rsid=1805007
|Gene=MC1R
|Chromosome=16
|position=89919709
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.0303
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MC1R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 76.8 | 22.3 | 0.9
| HCB | 98.5 | 1.5 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 98.5 | 1.5 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 99.0 | 1.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 98.2 | 1.8 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 94.1 | 5.9 | 0.0
| HapMapRevision=28
}}
[[rs1805007]], known as Arg151Cys or R151C, one of several SNPs in the [[MC1R]] gene associated with red [[hair color]] ([[redheads]]), and in redheaded females, linked to being more responsive to the [[anesthetics]] [[pentazocine]], [[nalbuphine]], and [[butorphanol]], often used by dentists [PMID 9571181, PMID 12663858, PMID 18488028]

The risk allele is [[rs1805007]](T), compared with the wild-type [[rs1805007]](C) allele.  

The risk allele has also been reported in several studies to be associated with increased risk for melanoma. For example, an odds ratio of 2.94 (CI: 1.04-8.31) has been reported for an Italian population {{PMID|16567973}}, and similarly an odds ratio of 2.9 has been reported for a Polish population {{PMID|16988943}}. 

[http://yannklimentidis.blogspot.com/2008/02/mc1r-genotypes-skin-cancer-risk-and.html Blog entry] about designing melanocortin analogs specific to these genotypes.

See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=155555&a=155555_AllelicVariant0004 OMIM 155555.0004]

{{ neighbor
| rsid = 2228479
| distance = 177
}}
{{ neighbor
| rsid = 1805008
| distance = 27
}}

{{PMID Auto GWAS
|PMID=17952075
|Trait=Blond vs. brown hair
|Title=Genetic determinants of hair, eye and skin pigmentation in Europeans
|RiskAllele=T
|Pval=2.0000000000000001E-13
|OR=2.34
|ORtxt=[1.69-3.24]
}}

{{omim
|id=266300
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2; SHEP2
|rsnum=1805007
}}

{{omim
|id=155555
|rsnum=1805007
|variant=0004
}}

{{PMID Auto
|PMID=21700618
|Title=Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
|OA=1
}}

{{ClinVar
|rsid=1805007
|Reversed=0
|FwdREF=C
|FwdALT=G,T
|REF=C
|ALT=G,T
|RSPOS=89986117
|CHROM=16
|GMAF=0.0302
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050168000000150517130101
|GENEINFO=MC1R:4157
|GENE_NAME=MC1R
|GENE_ID=4157
|WGT=0
|VC=SNV
|CLNALLE=2
|CLNHGVS=NC_000016.9:g.89986117C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=155555.0004
|CLNSIG=255
|CLNCUI=C2751296
|CLNDBN=Skin/hair/eye pigmentation 2, red hair/fair skin; Increased analgesia from kappa-opioid receptor agonist, female-specific; OCULOCUTANEOUS ALBINISM, TYPE II, MODIFIER OF; Parkinson disease, late-onset, susceptibility to
|Disease=Skin/hair/eye pigmentation 2; Increased analgesia from kappa-opioid receptor agonist; OCULOCUTANEOUS ALBINISM; Parkinson disease
|CLNACC=RCV000015385.24; RCV000015386.20; RCV000015387.24; RCV000015388.1
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.9697; 0.0303
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C2751296:613098
|COMMON=1
}}

{{PMID Auto
|PMID=17999355
|Title=A genomewide association study of skin pigmentation in a South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=19884608
|Title=Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.
|OA=1
}}

{{PMID Auto
|PMID=20042077
|Title=Genetic determinants of hair and eye colours in the Scottish and Danish populations.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{PMID Auto
|PMID=20670983
|Title=The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
}}

[[Freckling]]

{{PMID Auto
|PMID=23393597
|Title=Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23548203
  |Trait=Hair color
  |Title=Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
  |RiskAllele=C
  |Pval=3E-9
  |OR=.16
  |ORtxt=[0.10-0.22] unit decrease
  }}

{{PMID Auto
|PMID=25159867
|Title=Common variants modify the age of onset for basal cell carcinomas in Gorlin syndrome
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}