{{Rsnum
|rsid=1805008
|Gene=MC1R
|Chromosome=16
|position=89919736
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.02755
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MC1R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 74.3 | 25.7 | 0.0
| HCB | 97.7 | 2.3 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 95.9 | 4.1 | 0.0
| ASW | 90.9 | 9.1 | 0.0
| CHB | 97.7 | 2.3 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 97.0 | 3.0 | 0.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 96.6 | 3.4 | 0.0
| MKK | 99.3 | 0.7 | 0.0
| TSI | 91.2 | 8.8 | 0.0
| HapMapRevision=28
}}[[rs1805008]], known as Arg160Trp or R160W, is one of several SNPs in the [[MC1R]] gene associated with red [[hair color]] ([[redheads]]), in this case in an Irish population {{PMID|9665397}} although this has also been reported in Icelandic and Dutch populations {{PMID|18488028}}.

The risk allele is [[rs1805008]](T), compared with the wild-type [[rs1805008]](C) allele.  

[http://yannklimentidis.blogspot.com/2008/02/mc1r-genotypes-skin-cancer-risk-and.html blog] about designing melanocortin analogs specific to these genotypes.

See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=155555&a=155555_AllelicVariant0005 OMIM 155555.0005]

{{ neighbor
| rsid = 1805007
| distance = 27
}}
{{ neighbor
| rsid = 1805009
| distance = 402
}}

{{omim
|id=266300
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2; SHEP2
|rsnum=1805008
}}

{{omim
|id=155555
|rsnum=1805008
|variant=0005
}}

{{ClinVar
|rsid=1805008
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=89986144
|CHROM=16
|GMAF=0.0275
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050168000000150517110101
|GENEINFO=MC1R:4157
|GENE_NAME=MC1R
|GENE_ID=4157
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.89986144C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=155555.0005
|CLNSIG=5
|CLNCUI=C2751296
|CLNDBN=Skin/hair/eye pigmentation 2, red hair/fair skin; Increased analgesia from kappa-opioid receptor agonist, female-specific; OCULOCUTANEOUS ALBINISM, TYPE II, MODIFIER OF
|Disease=Skin/hair/eye pigmentation 2; Increased analgesia from kappa-opioid receptor agonist; OCULOCUTANEOUS ALBINISM
|CLNACC=RCV000015381.24; RCV000015382.20; RCV000015383.20
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9725; 0.02755
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C2751296:613098
|COMMON=1
}}

{{PMID Auto
|PMID=17999355
|Title=A genomewide association study of skin pigmentation in a South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=18392143
|Title=Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects.
|OA=1
}}

{{PMID Auto
|PMID=20042077
|Title=Genetic determinants of hair and eye colours in the Scottish and Danish populations.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{PMID Auto
|PMID=20670983
|Title=The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
}}

{{PMID Auto
|PMID=23100201
|Title=A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
|OA=1
}}

[[Melanoma]]

{{PMID Auto
|PMID=23393597
|Title=Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}