{{Rsnum
|rsid=1805009
|Gene=MC1R
|Chromosome=16
|position=89920138
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.005051
|Gene_s=MC1R,TUBB3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}[[rs1805009]], known as Asp294His or D294H and located in the [[MC1R]] gene, is the most common variant associated with red hair ([[redheads]]) and poor tanning ability in one study. {{PMID|7581459}}

The risk allele is [[rs1805009]](C), compared with the wild-type [[rs1805009]](G) allele.  

See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=155555&a=155555_AllelicVariant0001 OMIM 155555.0001]
{{ neighbor
| rsid = 1805008
| distance = 402
}}

[http://yannklimentidis.blogspot.com/2008/02/mc1r-genotypes-skin-cancer-risk-and.html blog] about designing melanocortin analogs specific to these genotypes.
{{omim
|id=155555
|rsnum=1805009
|variant=0001
}}{{ClinVar
|rsid=1805009
|Reversed=0
|FwdREF=G
|FwdALT=C
|REF=G
|ALT=C
|RSPOS=89986546
|CHROM=16
|GMAF=0.005
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050368000000050116110100
|GENEINFO=TUBB3:10381; MC1R:4157
|GENE_NAME=TUBB3; MC1R
|GENE_ID=10381; 4157
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.89986546G>C
|CLNORIGIN=1
|CLNSIG=5
|Tags=PM;PMC;S3D;SLO;VLD;G5;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9949; 0.005051
|CLNACC=RCV000015377.24
|CLNDBN=Skin/hair/eye pigmentation 2, red hair/fair skin
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=155555.0001
|COMMON=1
|Disease=Skin/hair/eye pigmentation 2
}}{{PMID Auto
|PMID=17999355
|Title=A genomewide association study of skin pigmentation in a South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{PMID Auto
|PMID=20670983
|Title=The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
}}