{{Rsnum
|rsid=1805010
|Gene=IL4R
|Chromosome=16
|position=27344882
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=T
|GMAF=0.4656
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL4R
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 23.9 | 54.0 | 22.1
| HCB | 30.9 | 44.1 | 25.0
| JPT | 20.4 | 36.3 | 43.4
| YRI | 28.1 | 48.6 | 23.3
| ASW | 28.1 | 49.1 | 22.8
| CHB | 30.9 | 44.1 | 25.0
| CHD | 22.2 | 54.6 | 23.1
| GIH | 39.6 | 43.6 | 16.8
| LWK | 25.5 | 44.5 | 30.0
| MEX | 21.1 | 49.1 | 29.8
| MKK | 21.9 | 42.6 | 35.5
| TSI | 32.4 | 52.0 | 15.7
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19515749
|Title=Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial
}}

{{PMID Auto
|PMID=19796199
|Title=Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease
}}

{{omim
|id=147781
|rsnum=1805010
|variant=0002
}}

{{PMID Auto
|PMID=22119518
|Title=Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population
}}

{{ClinVar
|rsid=1805010
|Reversed=0
|FwdREF=A
|FwdALT=C,G,T
|REF=A
|ALT=C,G,T
|RSPOS=27356203
|CHROM=16
|GMAF=0.4666
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05036800000017051f110100
|GENEINFO=IL4R:3566
|GENE_NAME=IL4R
|GENE_ID=3566
|WGT=0
|VC=SNV
|CLNALLE=2
|CLNHGVS=NC_000016.9:g.27356203A>G
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.5344; 0.4656; .
|CLNACC=RCV000015776.1; RCV000015777.1
|CLNDBN=Asthma, atopic; Acquired immunodeficiency syndrome, slow progression to
|CLNDSDB=MedGen
|CLNDSDBID=C0155877
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=147781.0002
|COMMON=1
|Disease=Asthma; Acquired immunodeficiency syndrome
}}

{{PMID Auto
|PMID=15660293
|Title=No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=17303794
|Title=Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=18625055
|Title=Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18781131
|Title=Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19759553
|Title=Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.
|OA=1
}}

{{PMID Auto
|PMID=19956098
|Title=Association analysis of SNPs in the IL4R locus with type I diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=19956109
|Title=The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
|OA=1
}}

{{PMID Auto
|PMID=20298583
|Title=Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=22376040
|Title=Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
}}

{{GET Evidence
|gene=IL4R
|aa_change=Ile75Val
|aa_change_short=I75V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805010
|overall_frequency_n=5054
|overall_frequency_d=10758
|overall_frequency=0.46979
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=0
|n_articles_annotated=0
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23299779
|Title=Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
|OA=1
}}

{{PMID Auto
|PMID=23924473
|Title=Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma
}}

{{PMID Auto
|PMID=22484276
|Title=Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: following up on Taiwan's neonatal hepatitis B immunization program.
}}

{{PMID Auto
|PMID=24782180
|Title=Increased Th17 Cell Frequency and Poor Clinical Outcome in Rheumatoid Arthritis Are Associated With a Genetic Variant in the IL4R Gene, rs1805010
}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}