{{Rsnum
|rsid=1805011
|Gene=IL4R
|Chromosome=16
|position=27362551
|Orientation=plus
|GMAF=0.2231
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=IL4R
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 83.2 | 15.0 | 1.8
| HCB | 83.2 | 15.3 | 1.5
| JPT | 82.3 | 15.9 | 1.8
| YRI | 11.6 | 52.7 | 35.6
| ASW | 26.3 | 40.4 | 33.3
| CHB | 83.2 | 15.3 | 1.5
| CHD | 84.3 | 14.8 | 0.9
| GIH | 87.1 | 12.9 | 0.0
| LWK | 11.8 | 54.5 | 33.6
| MEX | 81.0 | 15.5 | 3.4
| MKK | 28.2 | 47.4 | 24.4
| TSI | 80.4 | 19.6 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19956098
|Title=Association analysis of SNPs in the IL4R locus with type I diabetes
|OA=1
}}

{{PMID Auto
|PMID=20484924
|Title=Interleukin 13 and interleukin 4 receptor-? polymorphisms in rhinitis and asthma
}}

{{PMID Auto
|PMID=15660293
|Title=No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=17303794
|Title=Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19644854
|Title=A polymorphism within IL21R confers risk for systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=19759553
|Title=Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=19956109
|Title=The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
|OA=1
}}

{{PMID Auto
|PMID=20298583
|Title=Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{GET Evidence
|gene=IL4R
|aa_change=Glu400Ala
|aa_change_short=E400A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805011
|overall_frequency_n=2705
|overall_frequency_d=10758
|overall_frequency=0.251441
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.578
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23480403
|Title=Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
}}

{{PMID Auto
|PMID=23924473
|Title=Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{PMID Auto
|PMID=23706709
|Title=Genetic analysis of asthma exacerbations.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}