{{Rsnum
|rsid=1805015
|Gene=IL4R
|Chromosome=16
|position=27362859
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.2098
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL4R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 24.8 | 72.6
| HCB | 1.5 | 15.3 | 83.2
| JPT | 1.8 | 15.9 | 82.3
| YRI | 21.8 | 43.5 | 34.7
| ASW | 10.5 | 38.6 | 50.9
| CHB | 1.5 | 15.3 | 83.2
| CHD | 0.9 | 14.7 | 84.4
| GIH | 1.0 | 20.8 | 78.2
| LWK | 26.4 | 50.0 | 23.6
| MEX | 3.4 | 17.2 | 79.3
| MKK | 23.1 | 48.7 | 28.2
| TSI | 0.0 | 25.5 | 74.5
| HapMapRevision=28
}}

{{PMID|18927306|OA=1
}} among high-grade glioma cases rs1805016 (TT versus GT/GG) was significantly protective against mortality over time [hazard ratios (HR), 0.59; 95% confidence intervals (CI), 0.40-0.88]. The IL4R [[rs1805016]] and [[rs1805015]] TT genotypes were both found to be significantly associated with survival beyond 1 year among patients with high-grade glioma (HR, 0.44; 95% CI, 0.27-0.73 and HR, 0.63; 95% CI, 0.44-0.91, respectively)

{{ neighbor
| rsid = 1801275
| distance = 220
}}
{{ neighbor
| rsid = 17513769
| distance = 1
}}

{{PMID Auto
|PMID=19515749
|Title=Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial
}}

{{omim
|id=147781
|rsnum=1805015
|variant=0003
}}

{{PMID Auto
|PMID=22119518
|Title=Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population
}}

{{PMID Auto
|PMID=21867552
|Title=Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites
|OA=1
}}

{{ClinVar
|rsid=1805015
|Reversed=0
|FwdREF=T
|FwdALT=C
|REF=T
|ALT=C
|RSPOS=27374180
|CHROM=16
|GMAF=0.2097
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05016800000015051f110100
|GENEINFO=IL4R:3566
|GENE_NAME=IL4R
|GENE_ID=3566
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.27374180T>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=147781.0003
|CLNSIG=255
|CLNCUI=CN029238
|CLNDBN=Atopy, resistance to; Asthma, susceptibility to
|Disease=Atopy; Asthma
|CLNACC=RCV000015778.24; RCV000015779.1
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7902; 0.2098
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1869116:600807
|COMMON=1
}}

{{PMID Auto
|PMID=15660293
|Title=No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16024651
|Title=Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.
|OA=1
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=17303794
|Title=Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=18006935
|Title=An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.
}}

{{PMID Auto
|PMID=18256354
|Title=IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19264973
|Title=Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19956098
|Title=Association analysis of SNPs in the IL4R locus with type I diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=19956109
|Title=The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
|OA=1
}}

{{PMID Auto
|PMID=20219689
|Title=Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.
}}

{{PMID Auto
|PMID=20298583
|Title=Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.
|OA=1
}}

{{PMID Auto
|PMID=20401335
|Title=Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.
|OA=1
}}

{{PMID Auto
|PMID=20459687
|Title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=21111021
|Title=Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.
}}

{{GET Evidence
|gene=IL4R
|aa_change=Ser503Pro
|aa_change_short=S503P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805015
|overall_frequency_n=2495
|overall_frequency_d=10758
|overall_frequency=0.23192
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|pph2_score=0.743
|nblosum100=3
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23480403
|Title=Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
}}

{{PMID Auto
|PMID=23924473
|Title=Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma
}}

{{PMID Auto
|PMID=23979976
|Title=Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk
}}

{{PMID Auto
|PMID=22902050
|Title=Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=23462527
|Title=IL4R and IL13 polymorphic variants and development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to HBV vaccination or infection.
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}