{{Rsnum
|rsid=1805016
|Gene=IL4R
|Chromosome=16
|position=27363606
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.118
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=IL4R
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 0.0 | 12.6 | 87.4
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 9.6 | 51.4 | 39.0
| ASW | 20.0 | 45.5 | 34.5
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 8.0 | 92.0
| LWK | 11.2 | 46.7 | 42.1
| MEX | 0.0 | 3.4 | 96.6
| MKK | 5.8 | 52.6 | 41.7
| TSI | 0.0 | 7.8 | 92.2
| HapMapRevision=28
}}

{{PMID|18927306|OA=1
}} among high-grade glioma cases rs1805016 (TT versus GT/GG) was significantly protective against mortality over time [hazard ratios (HR), 0.59; 95% confidence intervals (CI), 0.40-0.88]. The IL4R [[rs1805016]] and [[rs1805015]] TT genotypes were both found to be significantly associated with survival beyond 1 year among patients with high-grade glioma (HR, 0.44; 95% CI, 0.27-0.73 and HR, 0.63; 95% CI, 0.44-0.91, respectively)

{{ neighbor
| rsid = 1801275
| distance = 527
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=17303794
|Title=Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19956098
|Title=Association analysis of SNPs in the IL4R locus with type I diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{GET Evidence
|gene=IL4R
|aa_change=Ser752Ala
|aa_change_short=S752A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805016
|overall_frequency_n=1525
|overall_frequency_d=10758
|overall_frequency=0.141755
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.328
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}