{{Rsnum
|rsid=1805018
|Gene=PLA2G7
|Chromosome=6
|position=46711566
|Orientation=minus
|GMAF=0.1281
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PLA2G7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 16.8 | 83.2
| HCB | 0.0 | 15.3 | 84.7
| JPT | 7.1 | 29.2 | 63.7
| YRI | 7.6 | 36.6 | 55.9
| ASW | 1.8 | 38.6 | 59.6
| CHB | 0.0 | 15.3 | 84.7
| CHD | 0.0 | 18.3 | 81.7
| GIH | 0.0 | 18.0 | 82.0
| LWK | 10.1 | 38.5 | 51.4
| MEX | 0.0 | 5.2 | 94.8
| MKK | 4.6 | 40.5 | 54.9
| TSI | 0.0 | 8.9 | 91.1
| HapMapRevision=28
}}

{{omim
|desc=ASTHMA AND ATOPY, SUSCEPTIBILITY TO
|id=601690
|rsnum=1805018
|variant=0002
}}

[[asthma]] related

{{Venter SNP
|rsid=1805018
|allele=G
|frequency=0.075
|uid=1103652858691
|type=heterozygous_SNP
|hugo=PLA2G7
|ensembl gene=ENSG00000146070
|ensembl transcript=ENST00000274793
|sift=TOLERATED
|disease=Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PLA2G7 deficiency) (MIM:601690). It is a trait which is present in 27% of Japanese. It could have a significant physiologic effect in the presence of inflammatory bodily responses.
}}

{{ClinVar
|rsid=1805018
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=46679303
|CHROM=6
|GMAF=0.1277
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x05036800000015051f110101
|GENEINFO=PLA2G7:7941
|GENE_NAME=PLA2G7
|GENE_ID=7941
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.46679303A>G
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8719; 0.1281
|CLNACC=RCV000008377.1
|CLNDBN=Asthma and atopy, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=601690.0002
|COMMON=1
|Disease=Asthma and atopy
}}

{{PMID Auto
|PMID=18204052
|Title=Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.
|OA=1
}}

{{PMID Auto
|PMID=20442857
|Title=Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
|OA=1
}}

{{GET Evidence
|gene=PLA2G7
|aa_change=Ile198Thr
|aa_change_short=I198T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805018
|overall_frequency_n=1135
|overall_frequency_d=10758
|overall_frequency=0.105503
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|pph2_score=0.001
|nblosum100=3
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}