{{Rsnum
|rsid=1805097
|Gene=IRS2
|Chromosome=13
|position=109782884
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2971
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IRS2
}}[[rs1805097]], also known as Gly1057Asp, is a SNP in the insulin receptor substrate-2 [[IRS2]] gene. The [[rs1805097]](G) allele is associated with the Gly, and the (A) allele with Asp.

A [[longevity]] study categorizing 677 participants as either long-lived (i.e. over 85 years old) or not (less than 85) somehow concluded that [[rs1805097]](A;A) individuals were about twice as likely to reach extreme old age (odds ratio 2.03, CI:1.39-2.99, p = .0003).{{PMID|19887537}}

{{omim
|desc=DIABETES, TYPE II, SUSCEPTIBILITY TO
|id=600797
|rsnum=1805097
|variant=0001
}}

{{PMID Auto
|PMID=19818665
|Title=Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
}}

{{ClinVar
|rsid=1805097
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=110435231
|CHROM=13
|GMAF=0.2981
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050068000000170416110100
|GENEINFO=IRS2:8660
|GENE_NAME=IRS2
|GENE_ID=8660
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000013.10:g.110435231C>T
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;PMC;VLD;G5A;G5;HD;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.7029; 0.2971
|CLNACC=RCV000009368.1
|CLNDBN=DIABETES, TYPE II, SUSCEPTIBILITY TO
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=600797.0001
|COMMON=1
|Disease=DIABETES
}}

{{PMID Auto
|PMID=18398040
|Title=Transcription factor 7-like 2 polymorphism and colon cancer.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18611262
|Title=Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
|OA=1
}}

{{PMID Auto
|PMID=18992263
|Title=Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
|OA=1
}}

{{PMID Auto
|PMID=19124510
|Title=Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
|OA=1
}}

{{GET Evidence
|gene=IRS2
|aa_change=Gly1057Asp
|aa_change_short=G1057D
|impact=protective
|qualified_impact=Low clinical importance, Uncertain protective
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805097
|overall_frequency_n=2288
|overall_frequency_d=9836
|overall_frequency=0.232615
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=1
|n_articles_annotated=1
|qualityscore_case_control=2
|in_omim=Y
|pph2_score=0.024
|nblosum100=4
|autoscore=2
|webscore=N
|variant_evidence=0
|clinical_importance=0
|summary_short=a.k.a Gly1057Asp, insulin receptor substrate-2 IRS2. The rs1805097(G) allele is associated with the Gly, and the (A) allele with Asp.  A longevity study concluded that rs1805097(A;A) individuals were about twice as likely to live over 85 y/o (odds ratio 2.03, CI:1.39-2.99, p = .0003). 
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}