{{Rsnum
|rsid=1805123
|Gene=KCNH2
|Chromosome=7
|position=150948446
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.1295
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=KCNH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 57.5 | 37.2 | 5.3
| HCB | 92.7 | 6.6 | 0.7
| JPT | 92.9 | 7.1 | 0.0
| YRI | 96.8 | 3.2 | 0.0
| ASW | 86.0 | 14.0 | 0.0
| CHB | 92.7 | 6.6 | 0.7
| CHD | 89.0 | 9.2 | 1.8
| GIH | 61.4 | 30.7 | 7.9
| LWK | 98.2 | 1.8 | 0.0
| MEX | 72.4 | 25.9 | 1.7
| MKK | 92.9 | 7.1 | 0.0
| TSI | 51.5 | 40.6 | 7.9
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19149796
|Title=Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study.
|OA=1
}}

{{PharmGKB
|RSID=rs1805123
|Name_s=K897T
|Gene_s=KCNH2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:12829173; PubMed ID:19019189
|Annotation=shortened QT interval
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164856856
}}

{{PMID Auto
|PMID=20507645
|Title=Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study
|OA=1
}}

{{PharmGKB
|RSID=rs1805123
|Name_s=KCNH2:K897T
|Gene_s=KCNH2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:15746444; PubMed ID:17709632
|Annotation=Associated with QT interval duration.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145088
}}

{{PharmGKB
|RSID=rs1805123
|Name_s=K897T
|Gene_s=KCNH2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:14975928; PubMed ID:18791070
|Annotation=Altered biophysics; creates phosphorylation site that inhibits channel
|Drugs=
|Drug Classes=
|Diseases=Acquired Long QT Syndrome (aLQTS); Long QT Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA164760865
}}

{{PharmGKB
|RSID=rs1805123
|Name_s=K897T
|Gene_s=KCNH2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:18222980
|Annotation=associated with higher incidence of atrial fibrillation
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164856857
}}

{{PMID Auto
|PMID=22690879
|Title=Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis
|OA=1
}}

{{ClinVar
|rsid=1805123
|Reversed=1
|FwdREF=A
|FwdALT=C
|REF=T
|ALT=G
|RSPOS=150645534
|CHROM=7
|GMAF=0.1291
|dbSNPBuildID=89
|SSR=0
|SAO=1
|VP=0x050178000000150517100100
|GENEINFO=KCNH2:3757
|GENE_NAME=KCNH2
|GENE_ID=3757
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.150645534T>G
|CLNORIGIN=1
|CLNSIG=1
|Tags=RV;PM;TPA;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD
|CAF=0.8705; 0.1295
|COMMON=1
|CLNACC=RCV000058152.1
|CLNDBN=not provided
|Disease=not provided
}}

{{PMID Auto
|PMID=17227789
|Title=The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study.
}}

{{PMID Auto
|PMID=17534376
|Title=Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects.
|OA=1
}}

{{PMID Auto
|PMID=18785031
|Title=Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study.
}}

{{PMID Auto
|PMID=19214780
|Title=In silico investigations on functional and haplotype tag SNPs associated with congenital long QT syndromes (LQTSs).
|OA=1
}}

{{PMID Auto
|PMID=19305408
|Title=Common variants at ten loci influence QT interval duration in the QTGEN Study.
|OA=1
}}

{{PMID Auto
|PMID=14760
|Title=Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings].
|OA=1
}}

{{PMID Auto
|PMID=10807545
|Title=Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population.
}}

{{PMID Auto
|PMID=11997281
|Title=Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes.
}}

{{PMID Auto
|PMID=12402336
|Title=DHPLC analysis of potassium ion channel genes in congenital long QT syndrome.
}}

{{PMID Auto
|PMID=14661677
|Title=Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome.
}}

{{GET Evidence
|gene=KCNH2
|aa_change=Lys897Thr
|aa_change_short=K897T
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805123
|overall_frequency_n=1819
|overall_frequency_d=10758
|overall_frequency=0.169083
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|in_pharmgkb=Y
|pph2_score=0.001
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=3
|autoscore=4
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=22688145
|Title=Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}