{{Rsnum
|rsid=1805794
|Gene=NBN
|Chromosome=8
|position=89978251
|Orientation=plus
|GMAF=0.3329
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=NBN
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 49.6 | 40.7 | 9.7
| HCB | 29.4 | 52.9 | 17.6
| JPT | 32.7 | 47.8 | 19.5
| YRI | 70.1 | 24.5 | 5.4
| ASW | 63.2 | 31.6 | 5.3
| CHB | 29.4 | 52.9 | 17.6
| CHD | 35.8 | 43.1 | 21.1
| GIH | 26.7 | 41.6 | 31.7
| LWK | 56.9 | 37.6 | 5.5
| MEX | 41.4 | 48.3 | 10.3
| MKK | 48.1 | 42.9 | 9.0
| TSI | 46.1 | 42.2 | 11.8
| HapMapRevision=28
}}{{PMID Auto
|PMID=20150366
|Title=DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
|OA=1
}}

{{PMID Auto
|PMID=21656575
|Title=Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma
}}

{{PMID Auto
|PMID=22070649
|Title=Genetic Variation in the NBS1 Gene Is Associated with Hepatic Cancer risk in a Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=21129811
|Title=Associations between polymorphisms in DNA repair genes and TP53 mutations in non-small cell lung cancer
}}

{{PMID Auto
|PMID=22631660
|Title=Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese
}}

{{PMID|16465622|OA=1
}} Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.

{{PMID|16857995|OA=1
}} Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.

{{PMID|18191955|OA=1
}} Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.

{{PMID|18579371|OA=1
}} Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions.

{{PMID|18638378|OA=1
}} Analysis of variants in DNA damage signalling genes in bladder cancer.

{{PMID|18701435|OA=1
}} Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.

{{PMID|18768505|OA=1
}} Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway.

{{PMID|19124499|OA=1
}} Association and interactions between DNA repair gene polymorphisms and adult glioma.

{{PMID|19276285|OA=1
}} Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.

{{PMID|19367277|OA=1
}} Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.

{{PMID|19393077|OA=1
}} Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis.

{{PMID|19523210|OA=1
}} Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer.

{{PMID|19584272|OA=1
}} Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.

{{PMID|19706757|OA=1
}} Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.

{{PMID|20004634}} Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.

{{PMID|20386703|OA=1
}} Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

{{PMID|20571895}} The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients.

{{PMID|20805886|OA=1
}} Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.

{{PMID|21166880}} Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population.

{{PMID|22413803}} DNA Repair System and Prostate Cancer Progression: The Role of NBS1 Polymorphism (rs1805794).

{{PMID|22430443|OA=1
}} Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma.

{{GET Evidence
|gene=NBN
|aa_change=Glu185Gln
|aa_change_short=E185Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1805794
|overall_frequency_n=3063
|overall_frequency_d=10758
|overall_frequency=0.284718
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-2
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23979977
|Title=NBS1 Glu185Gln polymorphism and cancer risk: update on current evidence
}}

{{PMID Auto
|PMID=24113799
|Title=Functional variants in NBS1 and cancer risk: evidence from a meta-analysis of 60 publications with 111 individual studies
}}

{{PMID Auto
|PMID=23283743
|Title=NBS1 rs1805794G>C polymorphism is associated with decreased risk of acute myeloid leukemia in a Chinese population.
}}

{{PMID Auto
|PMID=23381647
|Title=Association between the NBS1 Glu185Gln polymorphism and breast cancer risk: a meta-analysis.
}}

{{PMID Auto
|PMID=25073514
|Title=NBS1 Glu185Gln polymorphism and susceptibility to urinary system cancer: a meta-analysis
}}

{{PMID Auto
|PMID=25176580
|Title=NBN and XRCC3 genetic variants in childhood acute lymphoblastic leukaemia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}