{{Rsnum
|rsid=182549
|Gene=MCM6
|Chromosome=2
|position=135859184
|Orientation=plus
|GMAF=0.2332
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MCM6
}}Also known as "G/A(-22018)" and located in the [[MCM6]] but with influence on the lactase [[LCT]] gene, [[rs182549]] is one of two SNPs that is associated with the primary haplotype associated with hypolactasia, more commonly known as [[lactose intolerance]] in European Caucasian populations. [PMID 11788828, PMID 15114531]

In these populations, the [[rs182549(C)]] allele (as named in accordance with dbSNP) is both the more common allele and the one associated with lactose intolerance.

In populations of sub-Saharan Africans, though, the [[rs182549(C)]] allele is unlikely to be predictive of lactose intolerance, and other SNPs are predictive instead. [PMID 15106124, PMID 17159977]

* See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601806&a=601806_AllelicVariant0002 OMIM 601806.0002]

{{PharmGKB
|RSID=rs182549
|Name_s=A/G -22018
|Gene_s=MCM6
|Feature=
|Evidence=PubMed ID:15114531
|Annotation=Phenotype: This SNP is part of a haplotype that extends for > 1 Mb and includes rs4988235. the the A allele of rs182549 and the T allele of rs4988235 are associated with lactase persistance. The haplotype appears to be under strong recent positive selection in Northern- European derived populations. In European Americans, African Americans and East Asians, the alleles associated with lactase persistance were found to occur at frequencies roughly matching the rates of lactase persistance. Study population/ethnicity: European American, African American, East Asian, Scandinavian. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Lactose Intolerance
|Curation Level=Curated
|PharmGKB Accession ID=PA165363256
}}

{{omim
|id=601806
|rsnum=182549
|variant=0002
}}

{{PMID Auto
|PMID=22572735
|Title=Lactase persistence may have an independent origin in Tibetan populations from Tibet, China
}}

{{PMID|18974842|OA=1
}} Gender differences in genetic risk profiles for cardiovascular disease.

{{PMID|19326473|OA=1
}} Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

{{PMID|19668368|OA=1
}} Ancestry analysis in the 11-M Madrid bomb attack investigation.

{{PMID|20031626|OA=1
}} Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

{{PMID Auto
|PMID=23028602
|Title=Lactase persistence and lipid pathway selection in the Maasai.
|OA=1
}}

{{PMID Auto
|PMID=23029545
|Title=Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}