{{Rsnum
|rsid=1828591
|Chromosome=4
|position=144559628
|Orientation=plus
|GMAF=0.388
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 38.4 | 44.6 | 17.0
| HCB | 46.7 | 44.5 | 8.8
| JPT | 48.7 | 38.9 | 12.4
| YRI | 21.2 | 54.1 | 24.7
| ASW | 15.8 | 54.4 | 29.8
| CHB | 46.7 | 44.5 | 8.8
| CHD | 46.8 | 45.0 | 8.3
| GIH | 31.7 | 47.5 | 20.8
| LWK | 45.5 | 44.5 | 10.0
| MEX | 40.4 | 56.1 | 3.5
| MKK | 36.4 | 46.8 | 16.9
| TSI | 36.3 | 50.0 | 13.7
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19300482
|Trait=Chronic Obstructive Pulmonary Disease
|Title=A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
|RiskAllele=
|Pval=1E-7
|OR=1.38
|ORtxt=[1.17-1.63]
|OA=1
}}

{{PharmGKB
|RSID=rs1828591
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19300482; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A Genome-Wide Association Study in Pulmonary Disease, Chronic Obstructive (COPD): Identification of Two Major Susceptibility Loci. (Initial Sample Size: 823 cases, 810 controls; Replication Sample Size: 2,840 family members, 389 cases, 472 controls); (Region: 4q31.22; Reported Gene(s): HHIP; Risk Allele: rs1828591-?); (p-value= 0.0000001).This variant is associated with Pulmonary Disease, Chronic Obstructive.
|Drugs=
|Drug Classes=
|Diseases=Pulmonary Disease, Chronic Obstructive
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739913
}}

{{PMID|19300500|OA=1
}} A genome-wide association study of pulmonary function measures in the Framingham Heart Study.

{{PMID|19996190}} Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1828591
|overall_frequency_n=54
|overall_frequency_d=128
|overall_frequency=0.421875
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23886569
|Title=Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes
}}

{{PMID Auto
|PMID=23936167
|Title=Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls
|OA=1
}}

{{PMID Auto
|PMID=25073350
|Title=[Genetic aspects of occupational chronic obstructive lung disease under exposure to various risk factors]
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}