{{Rsnum
|rsid=1835740
|Chromosome=8
|position=97154685
|Orientation=minus
|GMAF=0.3343
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LOC101927066
|Gene_s=LOC101927066
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 37.2 | 58.4
| HCB | 33.6 | 48.2 | 18.2
| JPT | 53.1 | 37.2 | 9.7
| YRI | 6.1 | 39.5 | 54.4
| ASW | 5.3 | 31.6 | 63.2
| CHB | 33.6 | 48.2 | 18.2
| CHD | 27.5 | 54.1 | 18.3
| GIH | 21.8 | 51.5 | 26.7
| LWK | 3.6 | 40.0 | 56.4
| MEX | 3.4 | 37.9 | 58.6
| MKK | 12.2 | 55.1 | 32.7
| TSI | 2.9 | 43.1 | 53.9
| HapMapRevision=28
}}[[rs1835740]] is a SNP from the 8q22.1 chromosomal region, best known for harboring various genes involved in glutamate metabolism and transport.

A large study comprising over 5,000 [[migraine]] patients and over 10,000 matched controls, primarily from Europe, found that the [[rs1835740]](A) allele conferred a (slightly) higher risk for the disorder. The reported odds ratio was 1.18, (CI: 1.127–1.244, p = 1.69 × 10e-11).{{PMID|20802479|OA=1
}}. However this study has failed to replicate in 2 [http://blog.23andme.com/2011/06/24/snpwatch-23andme-research-findings-migraines-and-the-speed-of-science/ followups].

{{PMID Auto
|PMID=22072275
|Title=Genetics of migraine in the age of genome-wide association studies
|OA=1
}}

{{PMID Auto
|PMID=22103325
|Title=A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura
}}

{{PMID Auto
|PMID=21964821
|Title=Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1.
|OA=1
}}

{{PMID Auto
|PMID=22908361
|Title=A replication study of a GWAS finding in migraine does not identify association in a Spanish case-control sample.
}}

{{PMID Auto
|PMID=24674449
|Title=A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}