{{Rsnum
|rsid=184394424
|Gene=FREM1
|Chromosome=9
|position=14842561
|Orientation=plus
|GMAF=0.0004591
|Gene_s=FREM1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ClinVar
|ALT=T
|CAF=0.9995; 0.0004591
|CHROM=9
|CLNACC=RCV000023746.1; RCV000059636.1
|CLNALLE=1
|CLNDBN=Trigonocephaly 2; not provided
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C3280974:614485:3366
|CLNHGVS=NC_000009.11:g.14842559C>T
|CLNSIG=5
|CLNSRC=OMIM Allelic Variant; UniProtKB (variants)
|CLNSRCID=608944.0009; VAR_067916
|COMMON=0
|Disease=Trigonocephaly 2; not provided
|FwdALT=T
|FwdREF=C
|GENEINFO=FREM1:158326
|GENE_ID=158326
|GENE_NAME=FREM1
|REF=C
|RSPOS=14842559
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;KGPhase1;KGPROD;OTHERKG;LSD
|VC=SNV
|VP=0x050168000000000016100100
|WGT=0
|dbSNPBuildID=135
|rsid=184394424
}}{{PMID Auto
|PMID=21931569
|Title=Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
|OA=1
}}