{{Rsnum
|rsid=1858830
|Gene=MET
|Chromosome=7
|position=116672385
|Orientation=plus
|GMAF=0.4977
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=MET
}}[[rs1858830]], located in promoter of the [[MET]] gene, has been linked to a 2x increase in the risk of [[autism]] based on a study of ~700 families.{{PMID|17053076|OA=1
}}

From [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 OMIM 164860]:

"In case-control analysis, the relative risk for autism was 2.27 for the CC genotype and 1.67 for the GC genotype compared to the GG genotype."

{{PMID|19002214|OA=1
}} The association of [[rs1858830]] in the [[MET]] gene with [[autism]] failed to replicate in 325 multiplex families and 10 trios of the International Molecular Genetic Study of Autism Consortium (IMGSAC), although another [[MET]] SNP did associate with [[autism]] ([[rs38845]])
{{PMID Auto
|PMID=19360663
|Title=Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder
|OA=1
}}

{{PMID Auto
|PMID=19548256
|Title=Association of MET with social and communication phenotypes in individuals with autism spectrum disorder
}}

{{omim
|desc=AUTISM, SUSCEPTIBILITY TO, 9; AUTS9
|id=611015
|rsnum=1858830
}}
{{PMID Auto
|PMID=19681062
|Title=Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with Autistic disorder
}}

{{omim
|id=164860
|rsnum=1858830
|variant=0011
}}

{{PMID Auto
|PMID=22110649
|Title=Replication of the Association of a MET Variant with Autism in a Chinese Han Population
|OA=1
}}

{{PMID|17696172}} Disruption of cerebral cortex MET signaling in autism spectrum disorder.

{{PMID|19255034}} Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions.

{{PMID|20080979|OA=1
}} Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability.

{{PMID|20615438}} Further evidence for the role of MET in autism susceptibility.

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}