{{Rsnum
|rsid=1859345
|Gene=SPOCK1
|Chromosome=5
|position=137111731
|Orientation=plus
|GMAF=0.2241
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SPOCK1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 7.1 | 46.9 | 46.0
| HCB | 0.7 | 29.2 | 70.1
| JPT | 8.8 | 32.7 | 58.4
| YRI | 2.0 | 21.1 | 76.9
| ASW | 0.0 | 26.3 | 73.7
| CHB | 0.7 | 29.2 | 70.1
| CHD | 0.0 | 24.8 | 75.2
| GIH | 8.9 | 51.5 | 39.6
| LWK | 5.5 | 27.3 | 67.3
| MEX | 6.9 | 31.0 | 62.1
| MKK | 4.5 | 26.9 | 68.6
| TSI | 7.8 | 45.1 | 47.1
| HapMapRevision=28
}}
[[rs1859345]] is a SNP in the - get ready - "sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1" [[SPOCK1]] gene.

A study of 477 Caucasian women, followed up by replication studies in another ~1,600 and also 1,300+ Chinese women, found that several linked SNPs in the [[SPOCK1]] gene are associated with age at [[menarche]]. [[rs1859345]] replicated across all groups studied (p < 10e-3), with the minor (C) allele associated with a (slightly) earlier age at menarche.{{PMID|19282985|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}