{{Rsnum
|rsid=1859962
|Chromosome=17
|position=71112612
|Orientation=plus
|GMAF=0.3976
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene=CASC17
|Gene_s=CASC17
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 18.6 | 57.5 | 23.9
| HCB | 18.2 | 48.2 | 33.6
| JPT | 1.8 | 43.4 | 54.9
| YRI | 1.6 | 38.1 | 60.3
| ASW | 8.8 | 36.8 | 54.4
| CHB | 18.2 | 48.2 | 33.6
| CHD | 14.7 | 55.0 | 30.3
| GIH | 22.8 | 58.4 | 18.8
| LWK | 4.5 | 41.8 | 53.6
| MEX | 31.0 | 53.4 | 15.5
| MKK | 14.7 | 42.3 | 42.9
| TSI | 28.4 | 43.1 | 28.4
| HapMapRevision=28
}}
[[rs1859962]] is a SNP on chromosome 17q24.3, associated with increased risk for [[prostate cancer]] in several studies.

In a study of over 3,600 Caucasians with [[prostate cancer]], [[rs1859962]] is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the [[rs1859962]](G;G) risk genotype yields an odds ratio for developing [[prostate cancer]] of 1.28 (CI: 1.11-1.47, p=5.5x10e-4) and may account for 6.5% of population attributable risk.{{doi|10.1056/NEJMoa075819}}

[http://www.cancerpage.com/news/article.asp?id=11059 news] linked to [[Prostate cancer]] and [[type-2 diabetes]]

[http://cancergenetics.wordpress.com/2008/02/15/prostate-cancer-oldnew-snps-and-decodeprca/ cancer-genetics] these snps influence genetic risk for [[prostate cancer]]
*the [[haplotype]] [[rs6983267]] [[rs1016343]] [[rs4242384]] 
*[[rs7501939]] 
*[[rs1859962]]
*[[rs2660753]]
*[[rs9364554]]
*[[rs6465657]]
*[[rs10993994]]
*[[rs7931342]]
*[[rs2735839]]
*[[rs5945619]]
*[[rs10993994]]

{{GWAS Summary
|SNP=rs1859962
|PubMedID=17603485
|Condition=Prostate cancer
|Gene=Intergenic
|Risk Allele=G
|pValue=3.00E-010
|OR=1.2
|95CI=1.14-1.27
}}

{{PMID Auto GWAS
|PMID=18264097
|Trait=Prostate cancer
|Title=Multiple newly identified loci associated with prostate cancer susceptibility
|RiskAllele=G
|Pval=9.9999999999999995E-7
|OR=1.26
|ORtxt=[NR]
}}

{{omim
|desc=PROSTATE CANCER
|id=176807
|rsnum=1859962
}}

{{PharmGKB
|RSID=rs1859962
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17603485; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes (Initial Sample Size: 1,501 cases, 11,290 controls; Replication Sample Size: 1,992 cases, 3,058 controls; Risk Allele: rs1859962-G).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356666
}}
{{PMID Auto GWAS
|PMID=19767753
|Trait=Prostate cancer
|Title=Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
|RiskAllele=T
|Pval=2E-16
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs1859962
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17603485
|Annotation=The G allele of rs1859962 was found to contribute to the risk of prostate cancer in four populations of European descent.
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162356123
}}
{{PMID Auto
|PMID=21086507
|Title=GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)
}}

{{PMID Auto GWAS
|PMID=21743057
|Trait=None
|Title=Genome-wide association study identifies new prostate cancer susceptibility loci.
|RiskAllele=G
|Pval=3E-11
|OR=1.2700
|ORtxt=[1.18-1.37]
|OA=1
}}

{{PMID Auto
|PMID=21959049
|Title=Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=22665440
|Title=Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus
|OA=1
}}

{{PMID Auto
|PMID=18491292
|Title=Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
|OA=1
}}

{{PMID Auto
|PMID=18701471
|Title=Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=18974127
|Title=Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19058137
|Title=Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.
|OA=1
}}

{{PMID Auto
|PMID=19104501
|Title=Prostate cancer genomics: towards a new understanding.
|OA=1
}}

{{PMID Auto
|PMID=19318432
|Title=Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=19366828
|Title=Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19371897
|Title=Pathological outcomes associated with the 17q prostate cancer risk variants.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19727433
|Title=Cancer genetic association studies in the genome-wide age.
|OA=1
}}

{{PMID Auto
|PMID=20026053
|Title=WITHDRAWN: Relationships between 8q24 and 17q risk loci and sporadic or latent prostate cancer and the impacts of these loci on the clinicopathologic characteristics of prostate cancer.
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21456070
|Title=GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).
|OA=1
}}

{{PMID Auto
|PMID=21538423
|Title=Early onset prostate cancer has a significant genetic component.
|OA=1
}}

{{PMID Auto
|PMID=21557267
|Title=A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population.
}}

{{PMID Auto
|PMID=22077888
|Title=Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.
}}

{{PMID Auto
|PMID=22561070
|Title=8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1859962
|overall_frequency_n=87
|overall_frequency_d=128
|overall_frequency=0.679688
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=75
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24037955
|Title=The presence of prostate cancer at biopsy is predicted by a number of genetic variants
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}