{{Rsnum
|rsid=1861972
|Gene=EN2
|Chromosome=7
|position=155461298
|Orientation=plus
|GMAF=0.2181
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=EN2
}}[http://precedings.nature.com/documents/2366/version/1 nature] The inheritance of the AC haplotype of [[rs1861972]] – [[rs1861973]] in en2, the C allele of [[rs1811399]] in npas2, and the C allele of [[rs1234747]] may contribute to [[autism]] by affecting [[microRNA]]

{{PMID|18424904}} [[rs1861972]](A) + [[rs1861973]](C) haplotype assoc. with '''protective''' effect against autism in a study of 818 Han Chinese (184 diag. autistics, 225 unrelated volunteers, 409 randomly selected)

{{ neighbor
| rsid = 1861973
| distance = 152
}}

{{omim
|desc=AUTISM, SUSCEPTIBILITY TO, 10; AUTS10
|id=611016
|rsnum=1861972
}}

{{omim
|id=131310
|desc=ENGRAILED 2; EN2
|rsnum=1861972
}}
{{PMID Auto
|PMID=19270442
|Title=Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease
}}

{{PMID Auto
|PMID=20523082
|Title=Intronic single nucleotide polymorphisms of engrailed homeobox 2 modulate the disease vulnerability of autism in a han chinese population
}}

{{omim
|id=131310
|rsnum=1861972
|variant=0001
}}

{{PMID Auto
|PMID=22829897
|Title=Autism-Relevant Social Abnormalities and Cognitive Deficits in Engrailed-2 Knockout Mice
|OA=1
}}

{{PMID Auto
|PMID=15024396
|Title=Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder.
}}

{{PMID Auto
|PMID=16252243
|Title=Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus.
|OA=1
}}

{{PMID Auto
|PMID=17948868
|Title=Heterogeneous association between engrailed-2 and autism in the CPEA network.
}}

{{PMID Auto
|PMID=17948901
|Title=Association of the ENGRAILED 2 (EN2) gene with autism in Chinese Han population.
}}

{{PMID Auto
|PMID=19615670
|Title=Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.
|OA=1
}}

{{PMID Auto
|PMID=20050924
|Title=Family-based studies indicate association of Engrailed 2 gene with autism in an Indian population.
}}

{{PMID Auto
|PMID=20678243
|Title=Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk.
|OA=1
}}

{{PMID Auto
|PMID=22180456
|Title=Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function.
|OA=1
}}

{{PMID Auto
|PMID=22739633
|Title=The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}