{{Rsnum
|rsid=1864010
|Gene=INSR
|Chromosome=19
|position=7294494
|Orientation=minus
|GMAF=0.4275
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=INSR
}}{{PMID|17914103}} The [[INSR]] A-603G promoter [[rs1864010]] SNP, which is located within a known Sp1-binding site, was associated with the risk of [[colorectal cancer]], with carriers of the G allele having a decreased risk (odds ratios 0.71, CI: 0.54-0.93). Carrying the variant allele of the [[IRS1]] Gly972Arg [[rs1801278]] SNP further decreased the risk among the INSR-603G allele carriers (OR 0.28, 95% CI 0.11-0.70).
{{ neighbor
| rsid = 7508518
| distance = 607
}}{{PMID Auto
|PMID=16209714
|Title=The distribution of SNPs in human gene regulatory regions.
|OA=1
}}