{{Rsnum
|rsid=187084
|Gene=TLR9
|Chromosome=3
|position=52227015
|Orientation=plus
|GMAF=0.4027
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TLR9
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.6 | 46.9 | 42.5
| HCB | 13.1 | 53.3 | 33.6
| JPT | 27.4 | 43.4 | 29.2
| YRI | 9.5 | 39.5 | 51.0
| ASW | 12.3 | 42.1 | 45.6
| CHB | 13.1 | 53.3 | 33.6
| CHD | 11.0 | 54.1 | 34.9
| GIH | 21.8 | 43.6 | 34.7
| LWK | 12.7 | 38.2 | 49.1
| MEX | 22.4 | 55.2 | 22.4
| MKK | 9.6 | 35.9 | 54.5
| TSI | 24.5 | 50.0 | 25.5
| HapMapRevision=28
}}{{PMID Auto
|PMID=19505919
|Title=Toll-like Receptor Signaling Pathway Variants and Prostate Cancer Mortality
|OA=1
}}

{{PharmGKB
|RSID=rs187084
|Name_s=
|Gene_s=TWF2, TLR9
|Feature=
|Evidence=PubMed ID:18662133
|Annotation=The TLR-9 -1486C allele showed a strong association with high parasitemia (P< .001).
|Drugs=
|Drug Classes=
|Diseases=Malaria
|Curation Level=Curated
|PharmGKB Accession ID=PA164925714
}}

{{PMID Auto
|PMID=20422193
|Title=The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients
}}
{{PMID Auto
|PMID=21050493
|Title=Toll-Like Receptor Gene Polymorphisms are Associated with Susceptibility to Graves' Ophthalmopathy in Taiwan Males
|OA=1
}}

{{PMID Auto
|PMID=21633947
|Title=Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma
}}

{{PMID Auto
|PMID=22041559
|Title=[The correlation between polymorphisms of Toll-like receptor 2 and Toll-like receptor 9 and susceptibility to gastric cancer]
}}

{{PMID Auto
|PMID=22594374
|Title=Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study
|OA=1
}}

{{PMID Auto
|PMID=22714906
|Title=Involvement of toll-like receptor 9 polymorphism in cervical cancer development
|OA=1
}}

{{PMID Auto
|PMID=18396467
|Title=Genetic variation and haplotype structures of innate immunity genes in eastern India.
|OA=1
}}

{{PMID Auto
|PMID=18776126
|Title=Toll-like receptor 9 affects severity of IgA nephropathy.
|OA=1
}}

{{PMID Auto
|PMID=19134200
|Title=No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19284650
|Title=TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=20137629
|Title=[Relationship between polymorphism sites of IRF5, TLR-9 and SLE patients in Shandong Han population].
}}

{{PMID Auto
|PMID=20227302
|Title=Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.
}}

{{PMID Auto
|PMID=20646321
|Title=Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=21462132
|Title=[Association of single nucleotide polymorphisms in the promoter region of the TLR9 gene with childhood atopic asthma].
}}

{{PMID Auto
|PMID=21499878
|Title=Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan.
}}

{{PMID Auto
|PMID=21595536
|Title=Investigation of association between TLR9 gene polymorphisms and VKH in Japanese patients.
}}

{{PMID Auto
|PMID=21872627
|Title=Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
}}

{{PMID Auto
|PMID=22059466
|Title=A genetic variant in the promoter region of Toll-like receptor 9 and cervical cancer susceptibility.
}}

{{PMID Auto
|PMID=22228476
|Title=Lack of association of Toll-like receptor 9 polymorphisms with susceptibility to systemic lupus erythematosus in an Asian population: a meta-analysis.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs187084
|overall_frequency_n=53
|overall_frequency_d=128
|overall_frequency=0.414062
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22691414
|Title=Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
|OA=1
}}

{{PMID Auto
|PMID=22494793
|Title=Innate immunity gene single nucleotide polymorphisms and otitis media
}}

{{PMID Auto
|PMID=23420357
|Title=Meta-analysis demonstrates  association  between TLR polymorphisms and  rheumatoid arthritis
}}

{{PMID Auto
|PMID=23021866
|Title=Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents
|OA=1
}}

{{PMID Auto
|PMID=24004541
|Title=Association study of TLR-9 polymorphisms and systemic lupus erythematosus in Northern Chinese Han population
}}

{{PMID Auto
|PMID=24532514
|Title=Single nucleotide polymorphisms of toll-like receptor 7 and toll-like receptor 9 in hepatitis C virus infection patients from central china
|OA=1
}}

{{PMID Auto
|PMID=22948541
|Title=Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=23161283
|Title=SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?
|OA=1
}}

{{PMID Auto
|PMID=23731219
|Title=Toll-like receptor-9 in Spanish multiple sclerosis patients: an association with the gender.
}}

{{PMID Auto
|PMID=23990988
|Title=The TLR9 gene polymorphisms and the risk of cancer: evidence from a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=24971461
|Title=Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
}}

{{PMID Auto
|PMID=25248338
|Title=The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}