{{Rsnum
|rsid=187238
|Gene=IL18
|Chromosome=11
|position=112164265
|Orientation=minus
|GMAF=0.2277
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=IL18
}}[[rs187238]], also known as -137 G/C, is a SNP in the interleukin 18 [[IL18]] gene.

Based on studying autopsies of 700 men in the Helsinki Sudden Death Study, there was a significant interaction between IL-18 genotype and hypertension impacting on the risk of sudden cardiac death (SCD) due to coronary [[heart disease]] (CHD). Among [[rs187238]](G;G) homozygotes, hypertension was a major risk factor for SCD due to CHD (adjusted odds ratio 3.75, CI:1.78-7.91, p < 0.001) and hypertension also associated with larger coronary atherosclerotic plaque areas (p = 0.002) and the occurrence of complicated plaques (adjusted OR 8.38, CI: 2.39-29.33, p < 0.001). Among [[rs187238]](C) allele carriers, hypertension was not a significant risk factor for CHD-related SCD or CAD and did not associate with the development of coronary atherosclerotic plaques.{{PMID|19687159}} 

{{PMID Auto
|PMID=19455410
|Title=Interleukin 18 promoter variants (-137G&gt;C and -607C&gt;A) in patients with chronic hepatitis C: association with treatment response
}}

{{PMID Auto
|PMID=20331879
|Title=Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis
|OA=1
}}
{{PMID Auto
|PMID=20097272
|Title=Interleukin-18 promoter polymorphisms and risk of ischemic stroke
}}
{{PMID Auto
|PMID=21241672
|Title=Interleukin-18 Promoter Polymorphisms and Risk of Parkinson's disease in a Han Chinese Population
}}

{{PMID Auto
|PMID=21470492
|Title=Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus
}}

{{PMID Auto
|PMID=21510800
|Title=Association Between Promoter Variants of Interleukin-18 and Schizophrenia in a Han Chinese Population
}}

{{PMID Auto
|PMID=21611751
|Title=Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis
}}

{{PMID Auto
|PMID=22008665
|Title=The associations of IL-18 serum levels and promoter polymorphism with tacrolimus pharmacokinetics and hepatic allograft dysfunction in Chinese liver transplantation recipients
}}

{{PMID Auto
|PMID=21962565
|Title=Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events
}}

{{PMID Auto
|PMID=22664470
|Title=Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma
}}

{{PMID|15896202}} Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis.

{{PMID|16078996|OA=1
}} Association study of functional genetic variants of innate immunity related genes in celiac disease.

{{PMID|16443795}} Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

{{PMID|16542373|OA=1
}} Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.

{{PMID|16759385|OA=1
}} Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

{{PMID|16909454|OA=1
}} NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia.

{{PMID|17355643|OA=1
}} Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

{{PMID|17765248}} Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study.

{{PMID|17854431}} Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort.

{{PMID|17919265}} Polymorphism of interleukin-18 promoter influences the onset of kidney graft function after transplantation.

{{PMID|18043444}} Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection.

{{PMID|18599493}} Promoter polymorphism of interleukin-18 in angiographically proven coronary artery disease.

{{PMID|19073159}} Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease.

{{PMID|19178691|OA=1
}} Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery.

{{PMID|19229765}} Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis.

{{PMID|19961892}} Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients.

{{PMID|20304021}} Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders.

{{PMID|20478055|OA=1
}} Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.

{{PMID|20818961}} Inflammatory mediators gene polymorphisms in preeclampsia.

{{PMID|21840518}} Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage.

{{PMID|21969001|OA=1
}} Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

{{PMID|22325058}} Association of polymorphisms in interleukin-18 and interleukin-28B with Hepatitis B recurrence after liver transplantation in Chinese Han population.

{{PMID|22386125}} Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population.

{{PMID Auto
|PMID=23153245
|Title=Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=23546966
|Title=Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population
}}

{{PMID Auto
|PMID=24446726
|Title=Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans
}}

{{PMID Auto
|PMID=23073298
|Title=The IL18 gene and Hashimoto thyroiditis in children.
}}

{{PMID Auto
|PMID=23238919
|Title=Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=23302036
|Title=Gender-specific association of the interleukin 18 gene with symptomatic gallstone disease.
}}

{{PMID Auto
|PMID=23557801
|Title=Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients.
}}

{{PMID Auto
|PMID=23587914
|Title=Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=24969483
|Title=IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case-control studies
}}

{{PMID Auto
|PMID=25192895
|Title=Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}