{{Rsnum
|rsid=1876828
|Gene=CRHR1
|Chromosome=17
|position=45834159
|Orientation=minus
|GMAF=0.1162
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CRHR1
}}{{PMID|18565889}} The G allele at the rs1876828 SNP was associated with lower z scores (P = .02) in males but tended to have the opposite association in females (P = .09). CRHR1 polymorphisms may impact the risk of bone density deficits in patients treated with corticosteroids and antimetabolites in a sex-specific manner.

{{PharmGKB
|RSID=rs1876828
|Name_s=CRHR1:rs1876828
|Gene_s=CRHR1
|Feature=Intron
|Evidence=PubMed ID:15128701; PubMed ID:16113459; PubMed ID:16815632; PubMed ID:17258395
|Annotation=Haplotype tagging SNP.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145033
}}

{{PMID Auto
|PMID=15365580
|Title=Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans.
}}

{{PMID Auto
|PMID=19750552
|Title=Risk and resilience: genetic and environmental influences on development of the stress response.
|OA=1
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=22641026
|Title=Predicting inhaled corticosteroid response in asthma with two associated SNPs.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1876828
|overall_frequency_n=14
|overall_frequency_d=126
|overall_frequency=0.111111
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23726670
|Title=Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}