{{Rsnum
|rsid=1883025
|Gene=ABCA1
|Chromosome=9
|position=104902020
|Orientation=minus
|GMAF=0.2815
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ABCA1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 31.0 | 64.6
| HCB | 3.6 | 35.0 | 61.3
| JPT | 8.8 | 43.4 | 47.8
| YRI | 12.3 | 43.2 | 44.5
| ASW | 15.8 | 49.1 | 35.1
| CHB | 3.6 | 35.0 | 61.3
| CHD | 7.3 | 35.8 | 56.9
| GIH | 14.9 | 48.5 | 36.6
| LWK | 11.8 | 49.1 | 39.1
| MEX | 10.3 | 53.4 | 36.2
| MKK | 21.8 | 48.7 | 29.5
| TSI | 9.8 | 41.2 | 49.0
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=T
|Pval=1E-9
|OR=0.08
|ORtxt=[0.04-0.12] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs1883025
|Name_s=
|Gene_s=ABCA1
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 9q31.1; Reported Gene(s): ABCA1; Risk Allele: rs1883025-T); (p-value= 0.000000001).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740242
}}

{{omim
|id=600046
|rsnum=1883025
}}

{{PMID Auto
|PMID=21738485
|Title=Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study
|OA=1
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=T
|Pval=2E-33
|OR=0.9400
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22247473
|Title=Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models
|OA=1
}}

{{PMID Auto GWAS
|PMID=22399527
|Trait=None
|Title=Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|RiskAllele=T
|Pval=6E-10
|OR=0.1000
|ORtxt=None
|OA=1
}}

{{PMID|17430597|OA=1
}} Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms.

{{PMID|19951432|OA=1
}} Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

{{PMID|20160193|OA=1
}} Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

{{PMID|20339536|OA=1
}} Genome-wide association of lipid-lowering response to statins in combined study populations.

{{PMID|20385819|OA=1
}} Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

{{PMID|20385826|OA=1
}} Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1883025
|overall_frequency_n=39
|overall_frequency_d=126
|overall_frequency=0.309524
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24223199
|Title=Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study
|OA=1
}}

{{PMID Auto
|PMID=24970616
|Title=The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}