{{Rsnum
|rsid=1883832
|Gene=CD40
|Chromosome=20
|position=46118343
|Orientation=plus
|GMAF=0.2429
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CD40
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.9 | 41.6 | 3.5
| HCB | 46.0 | 43.1 | 10.9
| JPT | 27.7 | 53.6 | 18.8
| YRI | 98.6 | 1.4 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 46.0 | 43.1 | 10.9
| CHD | 44.0 | 40.4 | 15.6
| GIH | 53.5 | 39.6 | 6.9
| LWK | 93.6 | 6.4 | 0.0
| MEX | 55.2 | 37.9 | 6.9
| MKK | 85.3 | 14.1 | 0.6
| TSI | 42.2 | 55.9 | 2.0
| HapMapRevision=28
}}{{PMID|18097708}} Women with the TT genotype in rs1883832 had increased risk of osteopenia or [[osteoporosis]].

{{PMID|18287517|OA=1
}} rs1883832(T;T) influence [[lymphoma]] [odds ratio (OR)=1.6, 95% confidence interval (CI)=1.1-2.4]

{{ neighbor
| rsid = 4810485
| distance = 964
}}

{{PharmGKB
|RSID=rs1883832
|Name_s=
|Gene_s=CD40
|Feature=
|Evidence=PubMed ID:18287517
|Annotation=In genotype-phenotype studies, for the -1C>T SNP in the TNFRSF5 gene significantly reduced circulating soluble CD40 was observed in TT compared with CC carriers. The study showed that dendritic cells from those with -1TT versus -1CC genotypes exhibited lower CD40 cell surface expression.
|Drugs=
|Drug Classes=
|Diseases=Lymphoma
|Curation Level=Curated
|PharmGKB Accession ID=PA162191351
}}

{{PMID Auto
|PMID=20473910
|Title=A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis
|OA=1
}}
{{PMID Auto
|PMID=20504251
|Title=CD40-1C&gt;T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke
}}
{{PMID Auto
|PMID=20634952
|Title=CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility
|OA=1
}}
{{PMID Auto
|PMID=20682661
|Title=Influence of CD40 rs1883832 Polymorphism in Susceptibility to and Clinical Manifestations of Biopsy-proven Giant Cell Arteritis
}}

{{PMID Auto
|PMID=22087016
|Title=CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population
}}

{{PMID Auto
|PMID=22302395
|Title=Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis
}}

{{PMID Auto
|PMID=18045485
|Title=The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18591382
|Title=A novel polymorphism of the human CD40 receptor with enhanced function.
|OA=1
}}

{{PMID Auto
|PMID=18794853
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19159017
|Title=STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma.
|OA=1
}}

{{PMID Auto
|PMID=20577873
|Title=Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.
}}

{{PMID Auto
|PMID=21091218
|Title=The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study.
}}

{{PMID Auto
|PMID=22077624
|Title=A CD40 single-nucleotide polymorphism affects the lymphocyte profiles in the bronchoalveolar lavage of Japanese patients with sarcoidosis.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1883832
|overall_frequency_n=8668
|overall_frequency_d=10758
|overall_frequency=0.805726
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=85
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23166616
|Title=Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid Arthritis Patients
|OA=1
}}

{{PMID Auto
|PMID=23256180
|Title=Association of genetic polymorphisms in CD40 with susceptibility to SLE in the Korean population
}}

{{PMID Auto
|PMID=23613777
|Title=Association of SNPs of CD40 gene with multiple sclerosis in Russians.
|OA=1
}}

{{PMID Auto
|PMID=24828072
|Title=The SNP rs1883832 in CD40 Gene and Risk of Atherosclerosis in Chinese Population: A Meta-Analysis
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}