{{Rsnum
|rsid=1884051
|Gene=ESR1
|Chromosome=6
|position=151962144
|Orientation=plus
|GMAF=0.4343
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ESR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 52.2 | 38.9 | 8.8
| HCB | 22.6 | 48.2 | 29.2
| JPT | 23.9 | 41.6 | 34.5
| YRI | 16.3 | 46.3 | 37.4
| ASW | 29.8 | 49.1 | 21.1
| CHB | 22.6 | 48.2 | 29.2
| CHD | 24.8 | 46.8 | 28.4
| GIH | 29.7 | 48.5 | 21.8
| LWK | 27.3 | 50.0 | 22.7
| MEX | 29.3 | 44.8 | 25.9
| MKK | 31.4 | 47.4 | 21.2
| TSI | 46.1 | 43.1 | 10.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs1884051
|Name_s=
|Gene_s=ESR1
|Feature=
|Evidence=PubMed ID:18854778
|Annotation=The G allele of this SNP was associated with increased incidence of type 2 diabetes in a French cohort, but not in a Swedish cohort. However, this association was not significant following Bonferroni correction for analysis of 20 SNPs.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162360224
}}

{{PMID Auto
|PMID=20109228
|Title=Haplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians
|OA=1
}}

{{PMID Auto
|PMID=18053221
|Title=Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study.
|OA=1
}}

{{PMID Auto
|PMID=18678289
|Title=Polymorphisms in the estrogen receptor genes are associated with hip fractures in Chinese.
}}

{{PMID Auto
|PMID=19124506
|Title=Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19126777
|Title=Association of ESR1 gene tagging SNPs with breast cancer risk.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1884051
|overall_frequency_n=68
|overall_frequency_d=128
|overall_frequency=0.53125
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=59
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}