{{Rsnum
|rsid=1889018
|Gene=SREBF1
|Chromosome=17
|position=17831426
|Orientation=minus
|GMAF=0.3214
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SREBF1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.6 | 40.7 | 48.7
| HCB | 90.5 | 8.8 | 0.7
| JPT | 87.6 | 11.5 | 0.9
| YRI | 82.3 | 17.0 | 0.7
| ASW | 60.7 | 32.1 | 7.1
| CHB | 90.5 | 8.8 | 0.7
| CHD | 93.6 | 5.5 | 0.9
| GIH | 58.4 | 36.6 | 5.0
| LWK | 77.3 | 21.8 | 0.9
| MEX | 27.6 | 51.7 | 20.7
| MKK | 64.7 | 35.3 | 0.0
| TSI | 18.6 | 55.9 | 25.5
| HapMapRevision=28
}}[[rs1889018]] is one of several SNPs associated with the [[SREBF1]] gene that show a modest association with [[type-2 diabetes]].

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.12 (CI: 1.01-1.24, p=0.04) for the minor (risk) allele, [[rs1889018]](T). This allele was also associated with a surrogate measure of insulin sensitivity (p=0.03).{{PMID|18192539}}

{{PMID Auto
|PMID=17019602
|Title=Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}