{{Rsnum
|rsid=1892534
|Chromosome=1
|position=65640261
|Orientation=minus
|GMAF=0.4509
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs1892534]] is a SNP that was originally associated with C-reactive protein levels, and given other findings that suggest C-reactive protein levels may be predictive of cancer risk, was thought to be linked to cancer risk.

A large study pooling data from 3 Finnish studies totaling over 18,000 individuals concluded that while the [[rs1892534]](A) allele was not likely to be causative (relative to cancer), it is associated with increased risk for [[cancer]] overall. The odds ratio for 1 or 2 such alleles was 1.05 (CI: 0.90 - 1.23) and 1.2 (CI: 1.01 - 1.42) overall. Two other CRP SNPs ([[rs1169300]] and [[rs2464196]]) were specifically associated with increased [[lung cancer]] risk.  CRP SNPs were not associated with colorectal, prostate or breast cancer risk.{{PMID|20727736}}

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 11.6 | 43.8 | 44.6
| HCB | 78.8 | 21.2 | 0.0
| JPT | 79.6 | 19.5 | 0.9
| YRI | 23.8 | 52.4 | 23.8
| ASW | 33.3 | 40.4 | 26.3
| CHB | 78.8 | 21.2 | 0.0
| CHD | 77.1 | 22.0 | 0.9
| GIH | 20.8 | 48.5 | 30.7
| LWK | 13.6 | 51.8 | 34.5
| MEX | 36.2 | 39.7 | 24.1
| MKK | 13.5 | 46.8 | 39.7
| TSI | 15.7 | 44.1 | 40.2
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs1892534
|PubMedID=18439548
|Condition=C-reactive protein
|Gene=LEPR
|Risk Allele=G
|pValue=7.00E-021
|OR=
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs1892534
|Name_s=
|Gene_s=LEPR
|Feature=
|Evidence=PubMed ID:18439548; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study (Initial Sample Size: 6,345 women; Replication Sample Size: NR; Risk Allele: rs1892534-A). This variant is associated with C-reactive protein levels.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Metabolic Syndrome X; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356792
}}

{{PharmGKB
|RSID=rs1892534
|Name_s=
|Gene_s=LEPR
|Feature=
|Evidence=PubMed ID:18439548
|Annotation=In a GWAS of apparantly healthy women, seven loci were found to be significantly associated with C-Reactive protein levels. Nine SNPs were significant in LEPR, and this was the lead SNP.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161614204
}}

{{PMID Auto
|PMID=18439552
|Title=Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
|OA=1
}}

{{PMID Auto
|PMID=18728166
|Title=Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19401628
|Title=Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection.
|OA=1
}}

{{PMID Auto
|PMID=20031577
|Title=Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=21647738
|Title=Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|OA=1
}}

{{PMID Auto
|PMID=21931325
|Title=Gene polymorphisms of adiponectin and leptin receptor are associated with early onset of type 2 diabetes mellitus in the Taiwanese population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1892534
|overall_frequency_n=54
|overall_frequency_d=126
|overall_frequency=0.428571
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=53
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}