{{Rsnum
|rsid=1927911
|Gene=TLR4
|Chromosome=9
|position=117707776
|Orientation=minus
|GMAF=0.3857
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TLR4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.9 | 37.2 | 8.0
| HCB | 36.5 | 48.9 | 14.6
| JPT | 42.5 | 46.0 | 11.5
| YRI | 10.9 | 38.8 | 50.3
| ASW | 17.5 | 50.9 | 31.6
| CHB | 36.5 | 48.9 | 14.6
| CHD | 42.2 | 40.4 | 17.4
| GIH | 64.4 | 32.7 | 3.0
| LWK | 14.5 | 44.5 | 40.9
| MEX | 48.3 | 46.6 | 5.2
| MKK | 16.7 | 40.4 | 42.9
| TSI | 57.8 | 37.3 | 4.9
| HapMapRevision=28
}}The [[rs1927911]](T) allele was associated with a lower risk of nonfatal [[myocardial infarction]] (odds ratio 0.88, CI: 0.77 - 0.99) in 848 patients composed of both postmenopausal women and hypertensive men/women.{{PMID|18549840|OA=1
}}
{{PMID Auto
|PMID=23936790
|Title=Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients
|OA=1
}}
{{PMID Auto
|PMID=19380025
|Title=The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men
}}

{{PMID Auto
|PMID=20685742
|Title=Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma
}}

{{PMID Auto
|PMID=21081146
|Title=Impact of Toll-like receptor 4 polymorphisms on risk of cancer
}}

{{PMID Auto
|PMID=21921986
|Title=Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population
|OA=1
}}

{{PMID Auto
|PMID=22272615
|Title=Common variants in toll-like receptor 4 confer susceptibility to Alzheimer's disease in a Han Chinese population
}}

{{PMID Auto
|PMID=22238472
|Title=Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease
|OA=1
}}

{{PMID Auto
|PMID=17699831
|Title=Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.
|OA=1
}}

{{PMID Auto
|PMID=18298826
|Title=Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=18396467
|Title=Genetic variation and haplotype structures of innate immunity genes in eastern India.
|OA=1
}}

{{PMID Auto
|PMID=18422738
|Title=Study of Toll-like receptor gene loci in sarcoidosis.
|OA=1
}}

{{PMID Auto
|PMID=18586872
|Title=Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.
}}

{{PMID Auto
|PMID=19131814
|Title=Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.
|OA=1
}}

{{PMID Auto
|PMID=19500628
|Title=Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis.
}}

{{PMID Auto
|PMID=19503741
|Title=Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{PMID Auto
|PMID=19586676
|Title=Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.
|OA=1
}}

{{PMID Auto
|PMID=19753309
|Title=SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=20011079
|Title=Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.
|OA=1
}}

{{PMID Auto
|PMID=20200442
|Title=Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.
|OA=1
}}

{{PMID Auto
|PMID=20227302
|Title=Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}

{{PMID Auto
|PMID=21403649
|Title=Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia.
}}

{{PMID Auto
|PMID=23084080
|Title=The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=23639307
|Title=Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study
}}

{{PMID Auto
|PMID=24365597
|Title=Polymorphisms of the TLR4 gene and risk of gastric cancer
}}

{{PMID Auto
|PMID=22525209
|Title=Common polymorphisms in TLR4 gene associated with susceptibility to pulmonary tuberculosis in the Sudanese.
}}

{{PMID Auto
|PMID=22831837
|Title=Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma.
}}

{{PMID Auto
|PMID=24929142
|Title=Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer
}}

{{PMID Auto
|PMID=25216863
|Title=Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer susceptibility in Northeast China
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}