{{Rsnum
|rsid=1937506
|Chromosome=13
|position=67461239
|Orientation=plus
|GMAF=0.2236
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.3 | 41.6 | 53.1
| HCB | 1.5 | 27.0 | 71.5
| JPT | 5.3 | 31.0 | 63.7
| YRI | 2.7 | 21.9 | 75.3
| ASW | 7.0 | 35.1 | 57.9
| CHB | 1.5 | 27.0 | 71.5
| CHD | 0.9 | 23.9 | 75.2
| GIH | 8.9 | 35.6 | 55.4
| LWK | 1.8 | 30.0 | 68.2
| MEX | 13.8 | 43.1 | 43.1
| MKK | 7.7 | 36.5 | 55.8
| TSI | 3.0 | 38.6 | 58.4
| HapMapRevision=28
}}[[rs1937506]] has been reported in a large study to be associated with [[high blood pressure]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.33 (CI 1.04-1.69), and for homozygotes, 1.60 (CI 1.26-2.02). {{PMID|17554300|OA=1
}}

As follows from results of Replication of the Wellcome Trust genome-wide association study
of essential hypertension this SNP (rs1937506) only one of the top 6 SNPs which might be associated with essential hypertension in
Americans of European origin. This SNP shows a significant but opposite effect in Americans of
Hispanic origin. Each additional G allele of rs1937506 is associated with a 24.9 mmHg
decrease of systolic blood pressure (SBP) in European Americans and with a 27.7 mmHg increase in Hispanic Americans. 
Considering diastolic blood pressure (DBP) each additional G allele is associated with a 8.7 mmHg decrease of DBP in European Americans, whereas the results are non-significant for Hispanic Americans. [[http://www.ncbi.nlm.nih.gov/pubmed/18523456?ordinalpos=&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.SmartSearch&log$=citationsensor PMID: 18523456]]

{{PMID|19439027|OA=1
}} Dissecting complex traits: recent advances in hypertension genomics.

{{PMID|21228780}} Novel genetic variations associated with salt sensitivity in the Korean population.

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}