{{Rsnum
|rsid=1946518
|Gene=IL18
|Chromosome=11
|position=112164735
|Orientation=plus
|GMAF=0.4637
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=IL18
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 38.4 | 45.5 | 16.1
| HCB | 20.7 | 41.5 | 37.8
| JPT | 18.6 | 46.9 | 34.5
| YRI | 42.9 | 43.5 | 13.6
| ASW | 40.4 | 45.6 | 14.0
| CHB | 20.7 | 41.5 | 37.8
| CHD | 25.0 | 45.4 | 29.6
| GIH | 57.4 | 36.6 | 5.9
| LWK | 40.4 | 46.8 | 12.8
| MEX | 24.1 | 53.4 | 22.4
| MKK | 39.4 | 50.3 | 10.3
| TSI | 24.0 | 54.0 | 22.0
| HapMapRevision=28
}}{{PMID|18504197}} [[rs1946518]] and [[rs1946519]] may influence [[cervical cancer]]

{{ neighbor
| rsid = 1946519
| distance = 49
}}

{{PMID Auto
|PMID=19455410
|Title=Interleukin 18 promoter variants (-137G&gt;C and -607C&gt;A) in patients with chronic hepatitis C: association with treatment response
}}

{{PMID Auto
|PMID=20331879
|Title=Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis
|OA=1
}}
{{PMID Auto
|PMID=20097272
|Title=Interleukin-18 promoter polymorphisms and risk of ischemic stroke
}}
{{PMID Auto
|PMID=21241672
|Title=Interleukin-18 Promoter Polymorphisms and Risk of Parkinson's disease in a Han Chinese Population
}}

{{PMID Auto
|PMID=21395662
|Title=Relationship between SNP of the IL-18 and susceptibility to pulmonary TB in Chinese Han population
}}

{{PMID Auto
|PMID=21470492
|Title=Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus
}}

{{PMID Auto
|PMID=21510800
|Title=Association Between Promoter Variants of Interleukin-18 and Schizophrenia in a Han Chinese Population
}}

{{PMID Auto
|PMID=21611751
|Title=Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis
}}

{{PMID Auto
|PMID=22008665
|Title=The associations of IL-18 serum levels and promoter polymorphism with tacrolimus pharmacokinetics and hepatic allograft dysfunction in Chinese liver transplantation recipients
}}

{{PMID Auto
|PMID=21225442
|Title=Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis: protective effect of the T allele and T/T genotype at rs360722
}}

{{PMID Auto
|PMID=21962565
|Title=Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events
}}

{{PMID Auto
|PMID=22664470
|Title=Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma
}}

{{PMID Auto
|PMID=15896202
|Title=Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis.
}}

{{PMID Auto
|PMID=16078996
|Title=Association study of functional genetic variants of innate immunity related genes in celiac disease.
|OA=1
}}

{{PMID Auto
|PMID=16443795
|Title=Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.
}}

{{PMID Auto
|PMID=16542373
|Title=Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.
|OA=1
}}

{{PMID Auto
|PMID=16909454
|Title=NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia.
|OA=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=17854431
|Title=Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort.
}}

{{PMID Auto
|PMID=17919265
|Title=Polymorphism of interleukin-18 promoter influences the onset of kidney graft function after transplantation.
}}

{{PMID Auto
|PMID=18043444
|Title=Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection.
}}

{{PMID Auto
|PMID=18307517
|Title=Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.
|OA=1
}}

{{PMID Auto
|PMID=19073159
|Title=Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease.
}}

{{PMID Auto
|PMID=19178691
|Title=Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=19229765
|Title=Interleukin-18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis.
}}

{{PMID Auto
|PMID=19961892
|Title=Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients.
}}

{{PMID Auto
|PMID=20304021
|Title=Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders.
}}

{{PMID Auto
|PMID=20416077
|Title=Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
|OA=1
}}

{{PMID Auto
|PMID=20478055
|Title=Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21969001
|Title=Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
|OA=1
}}

{{PMID Auto
|PMID=22136483
|Title=Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis.
}}

{{PMID Auto
|PMID=22325058
|Title=Association of polymorphisms in interleukin-18 and interleukin-28B with Hepatitis B recurrence after liver transplantation in Chinese Han population.
}}

{{PMID Auto
|PMID=23153245
|Title=Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=23546966
|Title=Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population
}}

{{PMID Auto
|PMID=23739747
|Title=Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke
|OA=1
}}

{{PMID Auto
|PMID=23073298
|Title=The IL18 gene and Hashimoto thyroiditis in children.
}}

{{PMID Auto
|PMID=23238919
|Title=Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=23302036
|Title=Gender-specific association of the interleukin 18 gene with symptomatic gallstone disease.
}}

{{PMID Auto
|PMID=23557801
|Title=Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients.
}}

{{PMID Auto
|PMID=23587914
|Title=Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=24969483
|Title=IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case-control studies
}}

{{PMID Auto
|PMID=25192895
|Title=Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}