{{Rsnum
|rsid=1948
|Gene=CHRNB4
|Chromosome=15
|position=78625057
|Orientation=plus
|GMAF=0.3177
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHRNB4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 47.8 | 38.9 | 13.3
| HCB | 27.7 | 53.3 | 19.0
| JPT | 29.7 | 52.3 | 18.0
| YRI | 69.2 | 27.4 | 3.4
| ASW | 77.2 | 17.5 | 5.3
| CHB | 27.7 | 53.3 | 19.0
| CHD | 24.1 | 55.6 | 20.4
| GIH | 47.5 | 46.5 | 5.9
| LWK | 67.6 | 30.6 | 1.9
| MEX | 69.0 | 24.1 | 6.9
| MKK | 64.5 | 29.7 | 5.8
| TSI | 41.2 | 55.9 | 2.9
| HapMapRevision=28
}}

The (C;C) genotype (as published) of [[rs1948]] was calculated to represent a hazard ratio of 1.29 (CI: 1.01-1.63) for initiation of tobacco and alcohol use at an earlier age than average. A linked SNP also in the [[A5A3B4]] gene, [[rs8023462]], showed similiar association. {{PMID|18163978|OA=1
}}

{{PMID Auto
|PMID=17373692
|Title=No evidence for association between 19 cholinergic genes and bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=18165968
|Title=Identification of pharmacogenetic markers in smoking cessation therapy.
|OA=1
}}

{{PMID Auto
|PMID=18571741
|Title=Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
|OA=1
}}

{{PMID Auto
|PMID=18957677
|Title=The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=19029397
|Title=Nicotinic receptor gene variants influence susceptibility to heavy smoking.
|OA=1
}}

{{PMID Auto
|PMID=19492010
|Title=The genetic components of alcohol and nicotine co-addiction: from genes to behavior.
|OA=1
}}

{{PMID Auto
|PMID=22241830
|Title=Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.
|OA=1
}}

{{PMID Auto
|PMID=23872218
|Title=Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors
}}

{{PMID Auto
|PMID=22945651
|Title=Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}