{{Rsnum
|rsid=198358
|Gene=CLCN6
|Chromosome=1
|position=11844019
|Orientation=minus
|GMAF=0.2351
|Gene_s=CLCN6,NPPA-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 53.1 | 40.7 | 6.2
| HCB | 83.9 | 13.9 | 2.2
| JPT | 76.1 | 23.0 | 0.9
| YRI | 19.7 | 49.7 | 30.6
| ASW | 22.8 | 56.1 | 21.1
| CHB | 83.9 | 13.9 | 2.2
| CHD | 78.9 | 19.3 | 1.8
| GIH | 54.5 | 38.6 | 6.9
| LWK | 30.9 | 51.8 | 17.3
| MEX | 79.3 | 15.5 | 5.2
| MKK | 29.5 | 48.1 | 22.4
| TSI | 72.5 | 25.5 | 2.0
| HapMapRevision=28
}}
A study of ~15,000 Europeans found that increased circulating natriuretic peptide and thus lower [[blood pressure]] and [[hypertension]] were associated with SNPs [[rs17376328]](A), [[rs5068]], [[rs198358]](C), [[rs632793]](G)
{{PMID|19219041|OA=1
}}[http://blog.23andme.com/2009/02/17/snpwatch-common-genetic-variations-may-keep-blood-pressure-down/ 23andMe blog]

{{PMID|19326473|OA=1
}} Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

{{PMID|19439027|OA=1
}} Dissecting complex traits: recent advances in hypertension genomics.

{{PMID|20031578|OA=1
}} Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.

{{PMID|20407391}} Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study.

{{PMID|21276798}} Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.

{{PMID|22504314|OA=1
}} Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.

{{PMID Auto
|PMID=23315043
|Title=Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study
}}

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{{on chip | 23andMe v2}}
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{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}