{{Rsnum
|rsid=198389
|Gene=NPPB
|Chromosome=1
|position=11859214
|Orientation=plus
|GMAF=0.3173
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NPPB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 29.2 | 54.0 | 16.8
| HCB | 65.9 | 31.9 | 2.2
| JPT | 72.6 | 26.5 | 0.9
| YRI | 40.8 | 44.2 | 15.0
| ASW | 35.7 | 48.2 | 16.1
| CHB | 65.9 | 31.9 | 2.2
| CHD | 71.6 | 23.9 | 4.6
| GIH | 26.7 | 54.5 | 18.8
| LWK | 24.5 | 56.4 | 19.1
| MEX | 53.4 | 36.2 | 10.3
| MKK | 20.5 | 57.1 | 22.4
| TSI | 27.5 | 52.0 | 20.6
| HapMapRevision=28
}}{{PMID|17719005}} Brain natriuretic peptide (BNP) has been widely used for the diagnosis and prognostic evaluation of chronic heart failure (CHF) [[rs198389]] (T-381C), plasma BNP levels among the three genotypic categories, i.e., 2189 homozygous T-allele carriers (BNP 26.4+/-0.6pg/ml), 697 heterozygous carriers (35.0+/-1.1pg/ml), and 52 homozygous C-allele carriers (46.0+/-4.1pg/ml) indicated a co-dominant effect of the minor C-allele on elevating plasma BNP levels (P<0.0001)

{{PMID Auto
|PMID=19326473
|Title=Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
|OA=1
}}
{{PMID Auto
|PMID=19377085
|Title=The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49,279 subjects
}}

{{PMID Auto
|PMID=19413180
|Title=SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension
}}

{{PMID Auto
|PMID=19631175
|Title=Natriuretic peptides in the diagnosis and management of chronic heart failure.
|OA=1
}}

{{PMID Auto
|PMID=21273288
|Title=Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
|OA=1
}}

{{PMID Auto
|PMID=21276798
|Title=Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.
}}

{{PMID Auto
|PMID=21364112
|Title=The effect of the brain-type natriuretic peptide single-nucleotide polymorphism rs198389 on test characteristics of common assays.
|OA=1
}}

{{PMID Auto
|PMID=23315043
|Title=Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study
}}

{{PMID Auto
|PMID=23288489
|Title=Prospective evaluation of B-type natriuretic peptide concentrations and the risk of type 2 diabetes in women.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}