{{Rsnum
|rsid=198977
|Gene=KLK2
|Chromosome=19
|position=50878521
|Orientation=plus
|GMAF=0.2893
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=KLK2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.0 | 41.6 | 4.4
| HCB | 68.6 | 25.5 | 5.8
| JPT | 66.4 | 31.9 | 1.8
| YRI | 26.5 | 49.0 | 24.5
| ASW | 40.4 | 36.8 | 22.8
| CHB | 68.6 | 25.5 | 5.8
| CHD | 62.4 | 34.9 | 2.8
| GIH | 67.3 | 29.7 | 3.0
| LWK | 36.4 | 47.3 | 16.4
| MEX | 67.2 | 31.0 | 1.7
| MKK | 40.6 | 47.1 | 12.3
| TSI | 54.9 | 38.2 | 6.9
| HapMapRevision=28
}}In 2014 study [http://www.springerplus.com/content/3/1/295/abstract "Human kallikrein-2 gene and protein expression predicts prostate cancer at repeat biopsy"] [[rs198977]] T allele was found associated with prostate cancer at repeat biopsy with 1.8 odds ratio (95% CI: 1.04-3.13, p = 0.049). High serum hK2 level (> 0.163 ng/mL average in the study) correlated with [[rs198977]], and combined they predicted prostate cancer with OR 3.77 (95% CI: 1.94-7.32, p <0.0001). However, addition of these factors did not significantly improve existing baseline model with age, ethnic background, PSA, DRE, past histology, prostate volume, and family history as risk indicators. This study was conducted with quite selective sample group of 941 patients and is likely not applicable to general population, however it does convincingly back up the association found in earlier studies.

{{PMID Auto
|PMID=20424135
|Title=Blood Biomarker Levels to Aid Discovery of Cancer-Related Single-Nucleotide Polymorphisms: Kallikreins and Prostate Cancer
|OA=1
}}

{{PMID Auto
|PMID=21178268
|Title=Exploratory study of a KLK2 polymorphism as a prognostic marker in prostate cancer
|OA=1
}}

{{PMID Auto
|PMID=17085659
|Title=Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.
}}

{{PMID Auto
|PMID=20514297
|Title=2010 CUA Abstracts.
|OA=1
}}

{{GET Evidence
|gene=KLK2
|aa_change=Arg250Trp
|aa_change_short=R250W
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs198977
|overall_frequency_n=3328
|overall_frequency_d=10758
|overall_frequency=0.309351
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.002
|nblosum100=7
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24270797
|Title=Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}